ArticleProceedings of the National Academy of Sciences of the United States of America2017
Size- and speed-dependent mechanical behavior in living mammalian cytoplasm.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 133 citations in OpenAlex.
- Many dynein teams collectively generate high forces during the transport of large organelles.Biophysical journal · 2026Article
- Developmentally programmed changes in cytoplasmic mechanics revealed by active microrheology inbioRxiv : the preprint server for biology · 2026Article
- The biophysical properties of the bacterial nucleoid are dynamic, heterogeneous, and responsive to perturbations of cellular processes.bioRxiv : the preprint server for biology · 2026Article
- Network analysis of gene expression reveals regulators of cell viscosity and mechanical phenotype.Scientific reports · 2025Article
- Single-particle tracking of genetically encoded nanoparticles: Optimizing expression for cytoplasmic diffusion studies.Biophysical journal · 2025Article
- Structural and Mechanical Characterization of Collagen-Hyaluronan Hydrogels Used to Study Cancer Cell Invasion through the Bladder Wall.ACS biomaterials science & engineering · 2025Article
- Stick-slip motion and universal statistics of cargo transport within living cells.bioRxiv : the preprint server for biology · 2025Article
- A brief exploration of the physical properties of single living cells under dynamic loading conditions.Frontiers in bioengineering and biotechnology · 2025Article
- Anisotropy, topography and non-newtonian properties of cellular interiors probed by helical magnetic nanobots.Journal of micro-bio robotics · 2025Article
- Mechanical Cell Reprogramming on Tissue-Mimicking Hydrogels for Cancer Cell Transdifferentiation.Research (Washington, D.C.) · 2025Article
- Viscoelasticity of ECM and cells-origin, measurement and correlation.Mechanobiology in medicine · 2024Review
- Sequence-specific interactions determine viscoelasticity and aging dynamics of protein condensates.Nature physics · 2024Article
- Beyond stiffness: Multiscale viscoelastic features as biomechanical markers for assessing cell types and states.Biophysical journal · 2024Article
- Article
- A multiscale theory for spreading and migration of adhesion-reinforced mesenchymal cells.Journal of the Royal Society, Interface · 2023Article
- Viscoelastic Multiscale Mechanical Indexes for Assessing Liver Fibrosis and Treatment Outcomes.Nano letters · 2023Article
- Article
- Size- and position-dependent cytoplasm viscoelasticity through hydrodynamic interactions with the cell surface.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The role of the cortex in indentation experiments of animal cells.Biomechanics and modeling in mechanobiology · 2023Article
- Comparison of translational and rotational modes towards passive rheology of the cytoplasm of MCF-7 cells using optical tweezers.Frontiers in physics · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active transport in the cytoplasm plays critical roles in living cell physiology. However, the mechanical resistance that intracellular compartments experience, which is governed by the cytoplasmic material property, remains elusive, especially its dependence on size and speed. Here we use optical tweezers to drag a bead in the cytoplasm and directly probe the mechanical resistance with varying size
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.