Evidence map›Paper›PMID 28827327›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

Randal J Westrick, Kärt Tomberg, Amy E Siebert, Guojing Zhu, Mary E Winn, Sarah L Dobies, Sara L Manning, Marisa A Brake, Audrey C Cleuren, Linzi M Hobbs and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Suppressor mutations inGenome research · 2020
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Randal J WestrickDepartment of Biological Sciences, Oakland University, Rochester, MI 48309; ginsburg@umich.edu rjwestrick@oakland.edu.
Kärt TombergLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Amy E SiebertDepartment of Biological Sciences, Oakland University, Rochester, MI 48309.
Guojing ZhuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Mary E WinnBioinformatics and Biostatistics Core, Van Andel Research Institute, Grand Rapids, MI 49503.
Sarah L DobiesLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Sara L ManningLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Marisa A BrakeDepartment of Biological Sciences, Oakland University, Rochester, MI 48309.
Audrey C CleurenLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Linzi M HobbsDepartment of Biological Sciences, Oakland University, Rochester, MI 48309.
Lena M MishackDepartment of Biological Sciences, Oakland University, Rochester, MI 48309.
Alexander J JohnstonDepartment of Biological Sciences, Oakland University, Rochester, MI 48309.
Emilee KotnikLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
David R SiemieniakHoward Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109.
Jishu XuDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Jun Z LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-6727-0812
Thomas L SaundersTransgenic Animal Model Core, University of Michigan, Ann Arbor, MI 48109.
David GinsburgLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109; ginsburg@umich.edu rjwestrick@oakland.edu.ORCID 0000-0002-6436-8942
University of Michigan · USOakland University · USHoward Hughes Medical Institute · USVan Andel Institute · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
TRANSGENIC MODELS FOR THE STUDY OF FACTOR V FUNCTIONP01HL057346 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 1997 to 2013
$19.9M
The Molecular Genetics of HemostasisR35HL135793 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 2017 to 2023
$4.1M
Thrombosuppressive mechanisms of novel mutants discovered through an ENU mutagenesis screenR01HL135035 · NHLBI · OAKLAND UNIVERSITY · PI WESTRICK, RANDAL J · 2017 to 2021
$1.9M
Identification of the genetic regulators of Plasminogen Activator Inhibitor-1R15HL133907 · NHLBI · OAKLAND UNIVERSITY · PI WESTRICK, RANDAL J · 2016 to 2016
$433k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA046592NHLBI NIH HHS P01 HL057346NHLBI NIH HHS R01 HL135035NHLBI NIH HHS R15 HL133907NHLBI NIH HHS R35 HL135793
6 · The paper itself

Abstract

Factor V Leiden (

Indexed as

Actin-Related Protein 2Amino Acid SequenceAnimalsChromosome MappingDisease Models, AnimalEthylnitrosoureaExome SequencingFactor VFactor VIIIFemaleGenetic TestingHaploinsufficiencyHomozygoteHumansLipoproteinsMaleActin-Related Protein 2Actr2 protein, mouseEthylnitrosoureaFactor VFactor VIIIfactor V Leidenlipoprotein-associated coagulation inhibitorLipoproteinsENU mutagenesisFactor V Leidengenetic screentissue factor pathway inhibitorvenous thromboembolism

Identifiers

PMID28827327
PMCPMC5594664
OpenAlexW2953267252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.