ArticleThe Journal of biological chemistry2017
Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice.
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Role of Ovarian Stem Cells in Postnatal Oogenesis and Implications in Fertility Preservation.Advances in experimental medicine and biology · 2025Review
- Current Status and Future Prospects of Stem Cell Therapy for Infertile Patients with Premature Ovarian Insufficiency.Biomolecules · 2024Review
- Inhibition of EED activity enhances cell survival of female germline stem cell and improves the oocytes production during oogenesisOpen biology · 2023Article
- Review
- Germline stem cells in human.Signal transduction and targeted therapy · 2022Review
- Identification of Stem Cell-Like Cells in the Ovary.Tissue engineering and regenerative medicine · 2022Review
- Integrative analysis of the 3D genome structure reveals that CTCF maintains the properties of mouse female germline stem cells.Cellular and molecular life sciences : CMLS · 2022Article
- Germ cells of the mammalian female: A limited or renewable resource?†.Biology of reproduction · 2021Review
- Novel circGFRα1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by mFrontiers in cell and developmental biology · 2021Article
- The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure.Current molecular medicine · 2021Review
- Transcriptome profiling analysis of underlying regulation of growing follicle development in the chicken.Poultry science · 2020Article
- In Vitro Generation of Oocyte Like Cells and Their In Vivo Efficacy: How Far We have been Succeeded.Cells · 2020Review
- Molecular characteristics of early-stage female germ cells revealed by RNA sequencing of low-input cells and analysis of genome-wide DNA methylation.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germline stem cells are essential in the generation of both male and female gametes. In mammals, the male testis produces sperm throughout the entire lifetime, facilitated by testicular germline stem cells. Oocyte renewal ceases in postnatal or adult life in mammalian females, suggesting that germline stem cells are absent from the mammalian ovary. However, studies in mice, rats, and humans have recently provided evidence for ovarian female germline stem cells (FGSCs). A better understanding of the role of FGSCs in ovaries could help improve fertility treatments. Here, we developed a rapid and efficient method for isolating FGSCs from ovaries of neonatal mice. Notably, our FGSC isolation method could efficiently isolate on average 15 cell "strings" per ovary from mice at 1-3 days postpartum. FGSCs isolated from neonatal mice displayed the string-forming cell configuration at mitosis (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.