Evidence map›Paper›PMID 28827284›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation.

Dae Jin Song, Marina Miller, Andrew Beppu, Peter Rosenthal, Sudipta Das, Maya Karta, Christine Vuong, Amit Kumar Mehta, Michael Croft, David H Broide

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Orosomucoid-like protein 3, rhinovirus and asthma.World journal of critical care medicine · 2021
    Review
  2. Article
  3. Mechanisms Targeting the Unfolded Protein Response in Asthma.American journal of respiratory cell and molecular biology · 2021
    Review
  4. Orosomucoid-like 3 Supports Rhinovirus Replication in Human Epithelial Cells.American journal of respiratory cell and molecular biology · 2020
    Article
  5. Rhinovirus Attributes that Contribute to Asthma Development.Immunology and allergy clinics of North America · 2019
    Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Dae Jin SongDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0003-0647-3186
Marina MillerDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Andrew BeppuDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-9129-9535
Peter RosenthalDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Sudipta DasDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Maya KartaDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Christine VuongDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Amit Kumar MehtaDivision of Immune Regulation, La Jolla Institute, La Jolla, CA 92037.
Michael CroftDivision of Immune Regulation, La Jolla Institute, La Jolla, CA 92037.ORCID 0000-0002-6062-3635
David H BroideDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093; dbroide@ucsd.edu.
University of California San Diego · USLa Jolla Institute for Immunology · USKorea University · KR

Funding

TRM and airway inflammation and remodelingU19AI070535 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2006 to 2025
$34.2M
TRAINING IN MOLECULAR &CELL BIOLOGY OF ALLERGYT32AI007469 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 1994 to 2024
$6.9M
Epidemiology of Infectious Diseases and BiodefenseT32AI007535 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GRAD, YONATAN H, MURRAY, MEGAN B · 1998 to 2025
$4.8M
Chromosome 17q, allergic inflammation, and remodelingR01AI107779 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2013 to 2024
$4.7M
Eosinophil trafficking and chronic tissue damage induced by allergic inflammationR37AI038425 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2007 to 2016
$3.7M
GSDMB and mucosal allergic responseR01AI124236 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2017 to 2020
$2.4M
Eosinophil TraffickingR01AI038425 · NIAID · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BROIDE, DAVID H · 1996 to 2005
$1.8M
NIAID NIH HHS R01 AI038425NIAID NIH HHS R01 AI107779NIAID NIH HHS R01 AI124236NIAID NIH HHS R37 AI038425NIAID NIH HHS T32 AI007469NIAID NIH HHS T32 AI007535NIAID NIH HHS U19 AI070535
6 · The paper itself

Abstract

Orosomucoid like 3 (ORMDL3), a gene localized to chromosome 17q21, has been linked in epidemiologic studies to childhood asthma and rhinovirus (RV) infections. As the single nucleotide polymorphisms linking ORMDL3 to asthma are associated with increased expression of ORMDL3, we have used hORMDL3

Indexed as

2',5'-Oligoadenylate SynthetaseAnimalsAsthmaEndoribonucleasesEpithelial CellsInflammationInterferon-betaInterferonsLungMembrane ProteinsMiceMice, TransgenicPicornaviridae InfectionsReal-Time Polymerase Chain ReactionRhinovirusViral Load2-5A-dependent ribonuclease2',5'-Oligoadenylate SynthetaseEndoribonucleasesInterferon-betaInterferonsMembrane ProteinsOasl1 protein, mouseORMDL3 protein, human

Identifiers

PMID28827284
PMCPMC5605463
OpenAlexW2745380761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.