Evidence map›Paper›PMID 28827280›Full record

ArticleMolecular & cellular proteomics : MCP2017

Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity With Cysteines Across Human Proteomes.

Ling Fu, Keke Liu, Mingan Sun, Caiping Tian, Rui Sun, Carlos Morales Betanzos, Keri A Tallman, Ned A Porter, Yong Yang, Dianjing Guo and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
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  5. Article
  6. Ribosome Assembly and Repair.Annual review of cell and developmental biology · 2024
    Review
  7. Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Data Processing to Probe the Cellular Hydrogen Peroxide Landscape.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  17. Article
  18. Bull Sperm Capacitation Is Accompanied by Redox Modifications of Proteins.International journal of molecular sciences · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Ling FuFrom the ‡State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Radiation Medicine, Beijing 102206, China.
Keke LiuFrom the ‡State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Radiation Medicine, Beijing 102206, China.
Mingan Sun§State Key Laboratory of Agrobiotechnology and School of Life Sciences, The Chinese University of Hong Kong, China.
Caiping TianFrom the ‡State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Radiation Medicine, Beijing 102206, China.
Rui SunFrom the ‡State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Radiation Medicine, Beijing 102206, China.
Carlos Morales Betanzos‖Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Keri A Tallman**Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232.
Ned A Porter**Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232.
Yong Yang¶State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing 211198, China.
Dianjing Guo§State Key Laboratory of Agrobiotechnology and School of Life Sciences, The Chinese University of Hong Kong, China.
Daniel C Liebler‖Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Jing YangFrom the ‡State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Radiation Medicine, Beijing 102206, China; yangjing54@hotmail.com.ORCID 0000-0001-8486-273X
Beijing Proteome Research Center · CNVanderbilt University · USChina Pharmaceutical University · CNChinese University of Hong Kong · HK

Funding

Vanderbilt Proteome Characterization CenterU24CA159988 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LIEBLER, DANIEL C · 2011 to 2016
$13.9M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
NCI NIH HHS U24 CA159988NICHD NIH HHS U54 HD083211
6 · The paper itself

Abstract

Protein cysteinyl residues are the mediators of hydrogen peroxide (H

Indexed as

Amino Acid MotifsCell Line, TumorComputer SimulationCysteineHEK293 CellsHep G2 CellsHumansHydrogen PeroxideLysineOxidation-ReductionProtein ConformationProteomeProteomicsCysteineHydrogen PeroxideLysineProteome

Identifiers

PMID28827280
PMCPMC5629266
OpenAlexW2747696521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.