ArticleBMJ open2017
Risks of postextraction bleeding after receiving direct oral anticoagulants or warfarin: a retrospective cohort study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Local haemostatic measures after tooth removal in patients on antithrombotic therapy: a systematic review.Clinical oral investigations · 2019Pooled it
- Interventions for treating post-extraction bleeding.The Cochrane database of systematic reviews · 2018Pooled it
- Factors associated with postextraction bleeding in patients with hemophilia: a multicenter retrospective cohort study.Research and practice in thrombosis and haemostasis · 2026Article
- Local Hemostasis as the Critical Enabler for Safe Antithrombotic Therapy in Dentistry-Navigating Future Frontiers and Innovative Concepts.Journal of clinical medicine · 2026Review
- Risk of bleeding with dentoalveolar surgery in patients taking direct oral anticoagulants or vitamin K antagonists: A systematic review and meta-analysis.The Japanese dental science review · 2025Review
- Evaluation of postoperative bleeding and pain following tooth extraction in patients using direct oral anticoagulants: a prospective case-control study with blinded evaluation.BMC oral health · 2025Article
- Evaluation of postoperative bleeding risk after dental extractions in patients on antithrombotic medication: A comparison of machine learning and clinical experience.Clinical oral investigations · 2025Article
- Analysis of Postoperative Bleeding After Oral Surgery in Patients Receiving Anticoagulants: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2025Article
- A Unique Comparison of Tooth Extraction Before and After Emicizumab Prophylaxis in a Patient With Haemophilia A and Inhibitors.Case reports in dentistry · 2025Article
- Post-extraction bleeding in patients on direct oral anticoagulants.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Article
- Direct Oral Anticoagulants and Bleeding Management Following Tooth Extractions-A Prospective Cohort Study.Dentistry journal · 2024Article
- Exploring the Perioperative Use of DOACs, off the Beaten Track.Journal of clinical medicine · 2024Review
- Factors influencing postoperative bleeding after dental extraction in older adult patients receiving anticoagulation therapy.Clinical oral investigations · 2023Article
- Edoxaban use in the context of dental procedures: analysis from the EMIT-AF/VTE database.BDJ open · 2023Article
- Systematic review on the effects of the discontinuation of the anticoagulant therapy and the postoperative bleeding, in patients under new oral anticoagulants after dental extraction.Journal of clinical and experimental dentistry · 2023Review
- Perioperative Management of Oral Antithrombotics in Dentistry and Oral Surgery: Part 2.Anesthesia progress · 2023Review
- Hepatic and Renal Histotripsy in an Anticoagulated Porcine Model.Journal of vascular and interventional radiology : JVIR · 2023Article
- Peri-operative hemostatic management of tooth extraction in patients with hemophilia A, with and without inhibitors, receiving emicizumab prophylaxis.Haemophilia : the official journal of the World Federation of Hemophilia · 2023Article
- Local Tranexamic Acid for Preventing Hemorrhage in Anticoagulated Patients Undergoing Dental and Minor Oral Procedures: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2022Review
- Polyphosphate-crosslinked collagen scaffolds for hemostasis and alveolar bone regeneration after tooth extraction.Bioactive materials · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe effect of direct oral anticoagulants (DOACs) on the risk of bleeding after tooth extraction remains unclear. This study aimed to evaluate the incidence of postextraction bleeding among patients who received DOAC and vitamin K antagonists (VKAs), such as warfarin.
designThis study was a retrospective cohort analysis. Incidence rates and propensity score-matched regression models were used to compare the risks of bleeding after tooth extractions involving DOACs and VKAs.
settingThe study took place in a single university hospital in Japan.
participantsBetween April 2013 and April 2015, 543 patients underwent a total of 1196 simple tooth extractions. PRIMARY OUTCOME MEASURE: The primary outcome measure was the occurrence of postextraction bleeding, which was defined as bleeding that could not be stopped by biting down on gauze and required medical treatment between 30 min and 7 days after the extraction.
resultsA total of 1196 tooth extractions (634 procedures) in 541 patients fulfilled the study criteria, with 72 extractions (41 procedures) involving DOACs, 100 extractions (50 procedures) involving VKAs and 1024 extractions (543 procedures) involving no anticoagulants. The incidences of postextraction bleeding per tooth for the DOAC, VKA and no anticoagulant extractions were 10.4%, 12.0% and 0.9%, respectively. The incidences of postextraction bleeding per procedure for DOACs, VKAs and no anticoagulants were 9.7%, 10.0% and 1.1%, respectively. In comparison to the VKA extractions, the DOAC extractions did not significantly increase the risk of postextraction bleeding (OR 0.69, 95% CIs 0.24 to 1.97; p=0.49).
conclusionsThe risk of postextraction bleeding was similar for DOAC and VKA extractions.
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