Evidence map›Paper›PMID 28827112›Full record

ArticleBioorganic & medicinal chemistry letters2017

Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD

Xu Wang, Yong-Mo Ahn, Adam G Lentscher, Julia S Lister, Robert C Brothers, Malea M Kneen, Barbara Gerratana, Helena I Boshoff, Cynthia S Dowd

Open access · greenAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Inhibitors of NADInternational journal of molecular sciences · 2024
    Review
  4. Article
  5. Biomolecules · 2022
    Article
  6. Review
  7. Article
  8. Review
  9. Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effectsJournal of enzyme inhibition and medicinal chemistry · 2020
    Article
  10. Article
  11. Review
  12. Review
  13. Network-Based Metabolism-Centered Screening of Potential Drug Targets inFrontiers in cellular and infection microbiology · 2019
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xu WangDepartment of Chemistry, George Washington University, Washington DC 20052, United States.
Yong-Mo AhnTuberculosis Research Section, LCID, NIAID/NIH, Bethesda, MD 20892, United States.
Adam G LentscherDepartment of Chemistry, George Washington University, Washington DC 20052, United States.
Julia S ListerDepartment of Chemistry, George Washington University, Washington DC 20052, United States.
Robert C BrothersDepartment of Chemistry, George Washington University, Washington DC 20052, United States.
Malea M KneenDepartment of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, United States.
Barbara GerratanaDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, United States.
Helena I BoshoffTuberculosis Research Section, LCID, NIAID/NIH, Bethesda, MD 20892, United States.
Cynthia S DowdDepartment of Chemistry, George Washington University, Washington DC 20052, United States. Electronic address: cdowd@gwu.edu.
George Washington University · USNational Institutes of Health · USUniversity of Indianapolis · USUniversity of Maryland, College Park · US

Funding

Development Of New Chemotherapeutics For TuberculosisZIAAI000693 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2009 to 2025
$20.1M
Intramural NIH HHS ZIA AI000693
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD

Indexed as

Drug DesignAmide SynthasesAntitubercular AgentsDose-Response Relationship, DrugEnzyme InhibitorsHumansMicrobial Sensitivity TestsMolecular StructureMycobacterium tuberculosisStructure-Activity RelationshipAmide SynthasesAntitubercular AgentsEnzyme InhibitorsNAD+ synthaseAntibioticAntitubercularMycobacterium tuberculosisNadE

Identifiers

PMID28827112
PMCPMC6190683
OpenAlexW2743661436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.