ArticleHuman pathology2018
Carcinoma of the urethra.
Article in Human pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Locally advanced primary urethral carcinoma in an HIV-positive female patient: report of a case successfully managed with definitive concurrent chemoradiotherapy at a referral cancer center in Abidjan.Urology case reports · 2025Article
- Primary urethral cancer: Treatment patterns, responses and survival in localized, advanced and metastatic patients.BJUI compass · 2025Article
- Primary large cell neuroendocrine carcinoma of the urethra: a case report.Frontiers in urology · 2025Article
- Utility of The Paris System for Reporting Urinary Cytology in patients with HPV-positive urinary tract carcinoma.Cancer cytopathology · 2025Article
- Primary urethral carcinoma in female: An extremely rare case series at a single tertiary referral hospital and literature review.International journal of surgery case reports · 2024Article
- Bioprinted research models of urological malignancy.Exploration (Beijing, China) · 2024Review
- Epidemiology of Unconventional Histological Subtypes of Urethral Cancer.Urologia internationalis · 2023Article
- Primary urethral carcinoma with variant histology: A case report and literature review.Molecular and clinical oncology · 2022Article
- Chemotherapy combined with immunotherapy in primary female urethral squamous cell carcinoma: a case report.The Journal of international medical research · 2022Article
- Urethral metastasis from esophageal cancer: symptoms of dysuria and cystoscopic diagnosis.Oxford medical case reports · 2022Article
- A multimodality review of male urethral imaging: pearls and pitfalls with an update on urethral stricture treatment.The British journal of radiology · 2022Review
- The ultrasonographic characteristics of female periurethral solid masses.International urogynecology journal · 2022Article
- A Primary Urothelial Carcinoma Presenting as a Mid-Bulbar Urethral Stricture in a 30-Year-Old Male.Cureus · 2021Article
- Current Perspectives on the Diagnosis and Management of Primary Urethral Cancer: A Systematic Review.Research and reports in urology · 2021Review
- Voiding dysfunction due to female urethral carcinoma.International urogynecology journal · 2021Article
- Isolated urethral metastasis from appendiceal mucinous adenocarcinoma.Clinical imaging · 2020Article
- Primary urethral cancer: treatment patterns and associated outcomes.BJU international · 2020Article
- Leptomeningeal Disease as a Rare Complication of Primary Penile Urethral Cancer.Case reports in oncological medicine · 2020Article
- Prognosis of rare pathological primary urethral carcinoma.Cancer management and research · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcinomas ranged from 42 to 97 years (mean, 69.4 years; median, 70 years). There were 73 male and 33 female patients with a ratio of 2.2:1. In male patients, the tumors most frequently developed in the bulbous-membranous segment of the urethra. In female patients, the entire length of the urethra was typically involved. Microscopically, they were poorly differentiated carcinomas with hybrid squamous and urothelial features and developed from precursor intraepithelial conditions such as dysplasia and carcinoma in situ, which were frequently present in the adjacent urethral mucosa. High-risk human papilloma virus infection could be documented in 31.6% of these tumors. Follow-up information was available for 95 patients. Twenty-three patients died of the disease with a mean and median survival of 39 and 21 months, respectively. Urethral carcinomas are aggressive tumors with a high propensity for regional and distant metastases with mean and median survival of 39 and 21 months, respectively. Our observations have important implications for the management of patients with primary carcinoma of the urethra by defining them as a unique entity linked to human papilloma virus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.