ArticleNeuroscience2018
Organization of orientation-specific whisker deflection responses in layer 2/3 of mouse somatosensory cortex.
Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- An elastic segment of the whisker shaft enables coding of the whisking phase via whisker torsion in rats and mice.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Transient enhancement of stimulus-evoked activity in neocortex during sensory learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Interneuron-Targeted Disruption ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The structures and functions of correlations in neural population codes.Nature reviews. Neuroscience · 2022Review
- SmaRT2P: a software for generating and processing smart line recording trajectories for population two-photon calcium imaging.Brain informatics · 2022Article
- Stimulus Feature-Specific Control of Layer 2/3 Subthreshold Whisker Responses by Layer 4 in the Mouse Primary Somatosensory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The Influence of Neural Activity and Neural Cytoarchitecture on Cerebrovascular Arborization: A Computational Model.Frontiers in neuroscience · 2022Article
- Article
- Alternation of Neuronal Feature Selectivity Induced by Paired Optogenetic-Mechanical Stimulation in the Barrel Cortex.Frontiers in neural circuits · 2021Article
- Article
- Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice.Neuron · 2020Article
- Prediction of Choice from Competing Mechanosensory and Choice-Memory Cues during Active Tactile Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- On the development of optical peripheral nerve interfaces.Neural regeneration research · 2019Review
- Whisker-Mediated Touch System in Rodents: From Neuron to Behavior.Frontiers in systems neuroscience · 2019Review
- Organization of sensory feature selectivity in the whisker system.Neuroscience · 2018Review
- Cell Type Specific Representation of Vibro-tactile Stimuli in the Mouse Primary Somatosensory Cortex.Frontiers in neural circuits · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The rodent whisker-barrel system is characterized by its patterned somatotopic mapping between the sensory periphery and multiple regions of the brain. While somatotopy in the whisker system is established, we know far less about how preferences for stimulus orientation or other features are organized. Mouse somatosensation is an increasingly popular model for circuit-based dissection of perceptual decision making and learning, yet our understanding of how stimulus feature representations are organized in the cortex is incomplete. Here, we used in vivo two-photon calcium imaging to monitor activity of populations of layer (L) 2/3 neurons in the mouse primary somatosensory cortex during deflections of a single whisker in two orthogonal orientations (azimuthal or elevational). We split the population response to whisker deflections into an orientation-specific component and a non-specific component that reflected overall excitability in response to deflection of a single whisker. Orientation-specific responses were organized in a locally heterogeneous and spatially distributed manner. Correlations in the stimulus-independent trial-to-trial variability of pairs of neurons were higher among neurons that preferred the same orientation. These correlations depended on similarity in both orientation-specific and non-specific components of responses to single-whisker deflections. Our results shed light on L2/3 organization in mouse somatosensory cortex, and lay a foundation for dissecting circuit mechanisms of perceptual learning and decision-making during orientation discrimination tasks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.