ReviewSeminars in perinatology2017
The pathophysiology of human premature cervical remodeling resulting in spontaneous preterm birth: Where are we now?
Review in Seminars in perinatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interventions for Infection and Inflammation-Induced Preterm Birth: a Preclinical Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2023Pooled it
- Cervical pessary to prevent preterm birth in asymptomatic high-risk women: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2020Pooled it
- Biomechanical function of the murine cervix with elastic fiber deficiency.Journal of the mechanical behavior of biomedical materials · 2026Article
- Predictive Value of Cervical Length Measurement Combined With Shear Wave Elastography Parameters for Preterm Birth: A Retrospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Cervical cerclage outcomes by indication and cervical length across gestational-age thresholds: a historical cohort study.BMC pregnancy and childbirth · 2026Article
- Does suture number matter in transvaginal cervical cerclage? A propensity score-weighted cohort study.Archives of gynecology and obstetrics · 2026Observational
- The consequences of traditional cervical cauterization on cervical integrity and pregnancy: a cross-sectional study.Scientific reports · 2025Observational
- Cellular dynamics of cervical remodelling: insights from preterm and term labour.Archives of gynecology and obstetrics · 2025Observational
- Review
- The effect of cervical pessary on increasing gestational age at delivery in twin pregnancies with asymptomatic short cervix: a systematic review and meta-analysis of randomized controlled trials.AJOG global reports · 2024Review
- Effects of Ureaplasma parvum infection in the exosome biogenesis-related proteins in ectocervical epithelial cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Impact of bisphenol A on cell viability and inflammatory cytokine production in human cervical epithelial cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Modeling ascending Ureaplasma parvum infection through the female reproductive tract using vagina-cervix-decidua-organ-on-a-chip and feto-maternal interface-organ-on-a-chip.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Inflammatory Changes and Composition of Collagen during Cervical Ripening in Cows.Animals : an open access journal from MDPI · 2022Article
- Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer.Reproduction & fertility · 2022Review
- Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy.Journal of biomechanical engineering · 2022Article
- Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways.Frontiers in endocrinology · 2022Review
- Inflammatory response elicited by Ureaplasma parvum colonization in human cervical epithelial, stromal, and immune cells.Reproduction (Cambridge, England) · 2021Article
- Development and external validation of a nomogram for predicting preterm birth at < 32 weeks in twin pregnancy.Scientific reports · 2021Article
- Organ-on-chip of the cervical epithelial layer: A platform to study normal and pathological cellular remodeling of the cervix.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Approximately one in ten (approximately 500,000) pregnancies results in preterm birth (PTB) annually in the United States. Although we have seen a slight decrease in the U.S. PTB rate between 2007 and 2014, data from 2014 to 2015 shows the preterm birth rate has slightly increased. It is even more intriguing to note that the rate of PTB has not significantly decreased since the 1980s. In order to decrease the rate of spontaneous preterm birth (sPTB), it is imperative that we improve our understanding of normal and abnormal reproductive tissue structure and function and how these tissues interact with each other at a cellular and biochemical level. Since other chapters in this issue will be focusing on the myometrium and fetal membranes, the goal of this chapter is to focus on the compartment of the cervix. We will review the current literature on normal and abnormal human cervical tissue remodeling and identify gaps in knowledge. Our goal is also to introduce a revised paradigm of normal cervical tissue structure and function which will provide novel research opportunities that may ultimately lead to developing safe and effective interventions to significantly decrease the rate and complications of prematurity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.