ArticleeLife2017
A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 79 citations in OpenAlex.
- RNA polymerase II phosphorylation dynamics: from molecular mechanisms to human disease.RNA biology · 2026Review
- Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6.Nucleic acids research · 2026Article
- Regulation of RNA transcript elongation in metazoans and its relevance to disease.Nature reviews. Molecular cell biology · 2026Review
- The Promoter-Proximal Pause: A Decision Point Governing RNA Polymerase II Fate.Annual review of biochemistry · 2026Review
- Genetic alterations in SUPT6H are associated with neurodevelopmental disorders.Biochimica et biophysica acta. Molecular basis of disease · 2026Article
- Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6.bioRxiv : the preprint server for biology · 2026Article
- Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination.Genes & development · 2026Article
- Transcription quality control at the promoter-proximal checkpoint.Genes & development · 2025Review
- Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination.bioRxiv : the preprint server for biology · 2025Article
- Overlapping and distinct functions of SPT6, PNUTS, and PCF11 in regulating transcription termination.Nucleic acids research · 2025Article
- Chromatin Transcription Elongation - A Structural Perspective.Journal of molecular biology · 2025Review
- The CDK9-SPT5 Axis in Control of Transcription Elongation by RNAPII.Journal of molecular biology · 2025Review
- The fitness cost of spurious phosphorylation.The EMBO journal · 2024Article
- A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis.Nature communications · 2024Article
- Genome-wide regulation of Pol II, FACT, and Spt6 occupancies by RSC in Saccharomyces cerevisiae.Gene · 2024Article
- SPT6L, a newly discovered ancestral component of the plant RNA-directed DNA methylation pathway.Frontiers in plant science · 2024Article
- Transcriptional elongation control in developmental gene expression, aging, and disease.Molecular cell · 2023Review
- Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability.Trends in genetics : TIG · 2023Review
- Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.Nucleic acids research · 2023Article
- Interaction modules that impart specificity to disordered protein.Trends in biochemical sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Matthew A SdanoDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID http://orcid.org/0000-0001-6702-2755
James M FulcherDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID http://orcid.org/0000-0001-9033-3623
Sowmiya PalaniDepartment of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, United States.
Mahesh B ChandrasekharanDepartment of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, United States.
Timothy J ParnellDepartment of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, United States.
Frank G WhitbyDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
Tim FormosaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID http://orcid.org/0000-0002-8477-2483
Christopher P HillDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID https://orcid.org/0000-0001-6796-7740
University of Utah · US
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6MX-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1MBiochemical, Genetic, and Genomic Analysis of Nucleosome Reorganization by FACTR01GM064649 · NIGMS · UNIVERSITY OF UTAH · PI FORMOSA, TIMOTHY G · 2002 to 2022
$6.4MStructure, mechanism, and function of the histone chaperones Spt6 and FACTR01GM116560 · NIGMS · UNIVERSITY OF UTAH · PI FORMOSA, TIMOTHY G, HILL, CHRISTOPHER P. · 2016 to 2019
$1.2MLINEAR ION-TRAP /FOURIER TRANSFORM MASS SPECTROMETER: PROTEOMICS: DIABETESS10RR020883 · NCRR · UNIVERSITY OF UTAH · PI NELSON, CHAD P · 2005 to 2005
$500kMaldi/ToF/ToF Mass Spectrometer for the University of UtahS10RR025532 · NCRR · UNIVERSITY OF UTAH · PI NELSON, CHAD C · 2010 to 2010
$490kNCI NIH HHS P30 CA042014NCRR NIH HHS S10 RR020883NCRR NIH HHS S10 RR025532NIGMS NIH HHS P50 GM082545NIGMS NIH HHS R01 GM064649NIGMS NIH HHS R01 GM116560
Abstract
We determined that the tandem SH2 domain of
Indexed as
Protein Processing, Post-TranslationalCrystallography, X-RayHistone ChaperonesModels, MolecularPhosphorylationProtein BindingProtein ConformationRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscriptional Elongation FactorsTranscription, GeneticHistone ChaperonesRNA Polymerase IIRPB1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSPT6 protein, S cerevisiaeTranscriptional Elongation Factorsbiophysicschromosomesgeneshistone chaperonephosphorylationRNA polymerase IIS. cerevisiaeSH2 domainSpt6structural biologytranscription
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.