ArticleeLife2017
The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 36 citations in OpenAlex.
- Emerging Role and Potential Therapeutic Application of TRIM Proteins in Cardiovascular Diseases.Biomolecules · 2026Review
- Histidine decarboxylase inhibition attenuates cancer-associated muscle wasting.The Journal of experimental medicine · 2025Article
- Glucocorticoid-Mediated Skeletal Muscle Atrophy: Molecular Mechanisms and Potential Therapeutic Targets.International journal of molecular sciences · 2025Review
- Integrated transcriptomics and metabolomics studies reveal the therapeutic effects of Astragalus polysaccharides on cancer cachexia muscle atrophy.Scientific reports · 2025Article
- Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Zebrafish as a Versatile Model for Cardiovascular Research: Peering into the Heart of the Matter.Cells · 2025Review
- The role of mechanosignaling in the control of myocardial mass.American journal of physiology. Heart and circulatory physiology · 2025Review
- Filbertone Reduces Senescence in CNutrients · 2024Article
- The Effect of SERCA Activation on Functional Characteristics and Signaling of Rat Soleus Muscle upon 7 Days of Unloading.Biomolecules · 2023Article
- A novel method for visualizingiScience · 2023Article
- Calcineurin Signalling in Astrocytes: From Pathology to Physiology and Control of Neuronal Functions.Neurochemical research · 2023Review
- Zebrafish Models for Skeletal Muscle Senescence: Lessons from Cell Cultures and Rodent Models.Molecules (Basel, Switzerland) · 2022Review
- A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration.Bioelectricity · 2021Article
- Thyroid Hormone Receptor α Mutations Cause Heart Defects in Zebrafish.Thyroid : official journal of the American Thyroid Association · 2021Article
- Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial CaFrontiers in physiology · 2021Article
- MuRF1/TRIM63, Master Regulator of Muscle Mass.International journal of molecular sciences · 2020Review
- Emerging Strategies Targeting Catabolic Muscle Stress Relief.International journal of molecular sciences · 2020Review
- WNT regulates programmed muscle remodeling through PLC-β and calcineurin inDevelopment (Cambridge, England) · 2020Article
- Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1.The Journal of biological chemistry · 2020Article
- Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation.International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Hirohito ShimizuDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID http://orcid.org/0000-0002-9889-3892
Adam D LangenbacherDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID http://orcid.org/0000-0002-3752-0208
Jie HuangDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Kevin WangDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Georg OttoGenetics and Genomic Medicine, UCL Institute of Child Health, London, United Kingdom.ORCID http://orcid.org/0000-0002-3929-948X
Robert GeislerInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Yibin WangDepartment of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Jau-Nian ChenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID http://orcid.org/0000-0001-8807-3607
University of California, Los Angeles · USKarlsruhe Institute of Technology · DEUniversity College London · GB
Funding
Epigenomic Mechanisms of Heart FailureR01HL129639 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VONDRISKA, THOMAS M. · 2015 to 2018
$2.6MNovel Mechanisms of LncRNA Mediated Epigenetic Regulation in Cardiac HypertrophyR01HL143058 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VONDRISKA, THOMAS M. · 2018 to 2021
$2.2MNovel Mechanism of SR Calcium Regulation in Cardiac DysfunctionR01HL108186 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2011 to 2015
$1.9MElucidating the molecular mechanisms regulating embryonic cardiac rhythmicityR01HL096980 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN · 2010 to 2013
$1.5MSmall molecule screening for novel regulators of cardiac Ca2+ kinetics and rhythmR56HL126051 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN, NAKANO, ATSUSHI · 2015 to 2015
$457kNHLBI NIH HHS R01 HL096980NHLBI NIH HHS R01 HL108186NHLBI NIH HHS R01 HL129639NHLBI NIH HHS R01 HL143058NHLBI NIH HHS R56 HL126051
Abstract
Altered Ca
Indexed as
AnimalsAnimals, Genetically ModifiedCalcineurinCalciumCalcium SignalingEmbryo, NonmammalianForkhead Box Protein O1Gene DeletionGene Expression Regulation, DevelopmentalMuscle ProteinsMyocardiumMyocytes, CardiacMyofibrilsProteasome Endopeptidase ComplexProtein IsoformsProteolysisCalcineurinCalciumForkhead Box Protein O1foxo1a protein, zebrafishMuscle ProteinsProteasome Endopeptidase ComplexProtein IsoformsRNA, Small InterferingSodium-Calcium Exchangersodium-calcium exchanger 1Ubiquitin-Protein LigasesZebrafish ProteinsCa2+ signalingCalcineurincardiomyopathycell biologydevelopmental biologyFoxOMuRF1sarcomerestem cellszebrafish
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.