ArticleeLife2017
Anatomical and functional organization of the human substantia nigra and its connections.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Aberrant salience is selectively associated with ventral midbrain connectivity to the dorsal but not ventral striatum.Schizophrenia (Heidelberg, Germany) · 2026Article
- Mapping the dual functional organization of the substantia nigra.Molecular psychiatry · 2026Article
- Parkinson's disease subtypes and their relationship to dementia with Lewy bodies: a comparative neuroimaging analysis based on nigrostriatal degeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Postpartum psychosis is associated with elevated neuromelanin-MRI signal in the midbrain.Molecular psychiatry · 2026Article
- Machine learning-based optimization of dual subthalamic nucleus and substantia nigra targeting in deep brain stimulation.NPJ Parkinson's disease · 2026Article
- Microstimulation of the human dopaminergic midbrain enhances outcome-related happiness and reduces loss seeking.bioRxiv : the preprint server for biology · 2026Article
- Ferroptosis inhibition protects against α-synuclein-related neuronal cell death.Cell death & disease · 2025Article
- Largely Intact But Less Reliable and Distributed Neural Representations of Subjective Value in Human Opioid Addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Joint models reveal human subcortical underpinnings of choice and learning behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unveiling the neural network of freezing of gait in Parkinson's disease: A coordinate-based network study.Journal of Parkinson's disease · 2025Article
- Brain Imaging Phenotypes Associated with Polygenic Risk for Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin-Sensitive Magnetic Resonance Imaging andMovement disorders : official journal of the Movement Disorder Society · 2025Article
- Unravelling the nexus of stroke and dementia: Deciphering the role of secondary neurodegeneration in orchestrating cognitive decline.Neuroprotection (Chichester, England) · 2025Review
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- Right posterior theta reflects human parahippocampal phase resetting by salient cues during goal-directed navigation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease.European journal of neurology · 2025Article
- Decoding Salience: A Functional Magnetic Resonance Imaging Investigation of Reward and Contextual Unexpectedness in Memory Encoding and Retrieval.Human brain mapping · 2025Article
- Network localization of altered auditory and somatosensory sensitivity based on causal brain lesions.Brain communications · 2025Article
- Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease.NPJ Parkinson's disease · 2024Article
13 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
We investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project. We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive, motor arrangement. The medial SN connects with limbic striatal and cortical regions and encodes value (greater response to monetary wins than losses during fMRI), while the ventral SN connects with associative regions of cortex and striatum and encodes salience (equal response to wins and losses). The lateral SN connects with somatomotor regions of striatum and cortex and also encodes salience. Behavioral measures from delay discounting and flanker tasks supported a role for the value-coding medial SN network in decisional impulsivity, while the salience-coding ventral SN network was associated with motor impulsivity. In sum, there is anatomical and functional heterogeneity of human SN, which underpins value versus salience coding, and impulsive choice versus impulsive action.
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