ArticleeLife2017
Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens.
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In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 66 citations in OpenAlex.
- Identification of genetic markers of quinine partial resistance in Plasmodium falciparum.Nature microbiology · 2026Article
- Article
- Mapping the intellectual landscape of malaria drug repurposing: a systematic analysis of the 51 most cited studies.Malaria journal · 2026Review
- Plasmodium falciparum stomatin-like protein forms a putative complex with a metalloprotease in distinct mitochondrial loci.PLoS pathogens · 2026Article
- A chaperonin complex regulates organelle proteostasis in malaria parasites.PLoS pathogens · 2025Article
- Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins.The EMBO journal · 2025Article
- Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle.Nature communications · 2025Article
- A novel YGGT family protein is localized in the apicoplast and is essential for the organelle inheritance.Frontiers in cellular and infection microbiology · 2025Article
- A fast-acting inhibitor of blood-stagebioRxiv : the preprint server for biology · 2024Article
- An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins.bioRxiv : the preprint server for biology · 2024Article
- Comparative chemical genomics inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- New insights into apicoplast metabolism in blood-stage malaria parasites.Current opinion in microbiology · 2023Review
- Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis.Frontiers in cellular and infection microbiology · 2023Review
- FtsH degrades dihydrofolate reductase by recognizing a partially folded species.Protein science : a publication of the Protein Society · 2022Article
- Article
- GeneTargeter: AutomatedThe CRISPR journal · 2022Article
- Apicoplast Dynamics DuringFrontiers in cellular and infection microbiology · 2022Review
- Essential Genes of the Parasitic Apicomplexa.Trends in parasitology · 2021Review
- Some conditions apply: Systems for studying Plasmodium falciparum protein function.PLoS pathogens · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Katherine Amberg-JohnsonDepartment of Biochemistry, Stanford Medical School, Stanford, United States.ORCID http://orcid.org/0000-0003-2707-2912
Sanjay B HariDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.
Suresh M GanesanDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.
Hernan A LorenziDepartment of Infectious Disease, The J. Craig Venter Institute, Maryland, United States.
Robert T SauerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.
Jacquin C NilesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.
Ellen YehDepartment of Biochemistry, Stanford Medical School, Stanford, United States.ORCID http://orcid.org/0000-0003-3974-3816
Massachusetts Institute of Technology · USStanford Medicine · USJ. Craig Venter Institute · US
Funding
Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9MThe J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI TAN, GENE · 2014 to 2018
$29.7MREPRESSOR &ANTIREPRESSOR PROTEINS OF BACTERIOPHAGER01AI016892 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BAKER, TANIA A, SAUER, ROBERT T · 1985 to 2022
$13.0MMIT Center for Integrative Synthetic BiologyP50GM098792 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEISS, RON · 2013 to 2017
$11.0MEngineered Regulated RNA Localization and Transport in Biological SystemsDP2OD007124 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 2010 to 2010
$2.5MDefining the novel eukaryotic biology of the Apicomplexan plastidDP5OD012119 · OD · STANFORD UNIVERSITY · PI YEH, ELLEN · 2012 to 2016
$2.0MDeciphering apicoplast function during blood stage Plasmodium infectionK08AI097239 · NIAID · STANFORD UNIVERSITY · PI YEH, ELLEN · 2012 to 2016
$666kQuality Control of Membrane ProteinsF32GM116241 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HARI, SANJAY B · 2015 to 2016
$112kNIAID NIH HHS K08 AI097239NIAID NIH HHS R01 AI016892NIAID NIH HHS U19 AI110819NIGMS NIH HHS F32 GM116241NIGMS NIH HHS P50 GM098792NIGMS NIH HHS T32 GM007276NIH HHS DP2 OD007124NIH HHS DP5 OD012119Wellcome Trust
Abstract
The malaria parasite
Indexed as
Anti-Bacterial AgentsAntimalarialsApicoplastsDrug RepositioningDrug ResistanceErythrocytesFibroblastsGene ExpressionGene Knockdown TechniquesHigh-Throughput Screening AssaysHumansHydroxamic AcidsMembrane ProteinsMetalloproteasesMutationParasitic Sensitivity TestsactinoninAnti-Bacterial AgentsAntimalarialsFtsH1 protein, Toxoplasma gondiiHydroxamic AcidsMembrane ProteinsMetalloproteasesProtein IsoformsSmall Molecule Librariesantimalarialapicoplastbiochemistryinfectious diseasemicrobiologyP. falciparumToxoplasma gondii
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.