ArticleeLife2017
Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short-Term Spatial Memory via Multiple Ionic and Signaling Mechanisms.Advanced biology · 2026Article
- Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks.Function (Oxford, England) · 2025Article
- Inhibiting aberrant seizure-induced neurogenesis by temozolomide improves cognitive impairments associated with long-term amygdala kindling.Frontiers in neuroscience · 2025Article
- T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells.Hippocampus · 2023Article
- Adult-born neurons add flexibility to hippocampal memories.Frontiers in neuroscience · 2023Review
- Dominant role of adult neurogenesis-induced structural heterogeneities in driving plasticity heterogeneity in dentate gyrus granule cells.Hippocampus · 2022Article
- Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.iScience · 2022Article
- Article
- Evidences for Adult Hippocampal Neurogenesis in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Ion-channel regulation of response decorrelation in a heterogeneous multi-scale model of the dentate gyrus.Current research in neurobiology · 2021Article
- Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- GABAergic Input Affects Intracellular Calcium Levels in Developing Granule Cells of Adult Rat Hippocampus.International journal of molecular sciences · 2020Article
- Quantitative properties of a feedback circuit predict frequency-dependent pattern separation.eLife · 2020Article
- Heterogeneities in intrinsic excitability and frequency-dependent response properties of granule cells across the blades of the rat dentate gyrus.Journal of neurophysiology · 2020Article
- Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons.Cell reports · 2020Article
- Forgetting at biologically realistic levels of neurogenesis in a large-scale hippocampal model.Behavioural brain research · 2019Article
- Disparate forms of heterogeneities and interactions among them drive channel decorrelation in the dentate gyrus: Degeneracy and dominance.Hippocampus · 2019Article
- Multifaceted circuit functions of adult-born neurons.F1000Research · 2019Review
- A Pool of Postnatally Generated Interneurons Persists in an Immature Stage in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In adult neurogenesis young neurons connect to the existing network via formation of thousands of new synapses. At early developmental stages, glutamatergic synapses are sparse, immature and functionally 'silent', expressing mainly NMDA receptors. Here we show in 2- to 3-week-old young neurons of adult mice, that brief-burst activity in glutamatergic fibers is sufficient to induce postsynaptic AP firing in the absence of AMPA receptors. The enhanced excitability of the young neurons lead to efficient temporal summation of small NMDA currents, dynamic unblocking of silent synapses and NMDA-receptor-dependent AP firing. Therefore, early synaptic inputs are powerfully converted into reliable spiking output. Furthermore, due to high synaptic gain, small dendritic trees and sparse connectivity, neighboring young neurons are activated by different distinct subsets of afferent fibers with minimal overlap. Taken together, synaptic recruitment of young neurons generates sparse and orthogonal AP firing, which may support sparse coding during hippocampal information processing.
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