ArticleeLife2017
Genetic variation in adaptability and pleiotropy in budding yeast.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 90 citations in OpenAlex.
- Pervasive weak incompatibilities shape phenotypic variation and genome evolution in yeast hybrids.Nature communications · 2026Article
- Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistance.Nature communications · 2026Article
- Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution.Nature ecology & evolution · 2026Article
- Historical contingency limits adaptive diversification in a spatially structured environment.Evolution letters · 2026Article
- Effects of resource packaging on the adaptative and pleiotropic consequences of evolution.NPJ systems biology and applications · 2025Article
- Resource presentation dictates genetic and phenotypic adaptation in yeast.BMC ecology and evolution · 2025Article
- Article
- Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction.bioRxiv : the preprint server for biology · 2024Article
- Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes.Molecular systems biology · 2024Article
- Correlated Allele Frequency Changes Reveal Clonal Structure and Selection in Temporal Genetic Data.Molecular biology and evolution · 2024Article
- Convergent genetic adaptation ofFrontiers in molecular biosciences · 2024Article
- Experimental evolution for cell biology.Trends in cell biology · 2023Review
- Detecting natural selection in trait-trait coevolution.BMC ecology and evolution · 2023Article
- Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network.EMBO reports · 2023Article
- Identifying Targets of Selection in Laboratory Evolution Experiments.Journal of molecular evolution · 2023Review
- Epistasis and evolution: recent advances and an outlook for prediction.BMC biology · 2023Review
- Review
- Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return epistasis.G3 (Bethesda, Md.) · 2022Article
- Adaptive evolvability through direct selection instead of indirect, second-order selection.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Review
- Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes.Current opinion in genetics & development · 2022Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Evolution can favor organisms that are more adaptable, provided that genetic variation in adaptability exists. Here, we quantify this variation among 230 offspring of a cross between diverged yeast strains. We measure the adaptability of each offspring genotype, defined as its average rate of adaptation in a specific environmental condition, and analyze the heritability, predictability, and genetic basis of this trait. We find that initial genotype strongly affects adaptability and can alter the genetic basis of future evolution. Initial genotype also affects the pleiotropic consequences of adaptation for fitness in a different environment. This genetic variation in adaptability and pleiotropy is largely determined by initial fitness, according to a rule of declining adaptability with increasing initial fitness, but several individual QTLs also have a significant idiosyncratic role. Our results demonstrate that both adaptability and pleiotropy are complex traits, with extensive heritable differences arising from naturally occurring variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.