Evidence map›Paper›PMID 28826484›Full record

ArticleeLife2017

Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems.

Sukrit Silas, Patricia Lucas-Elio, Simon A Jackson, Alejandra Aroca-Crevillén, Loren L Hansen, Peter C Fineran, Andrew Z Fire, Antonio Sánchez-Amat

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 104 citations in OpenAlex.

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  13. Applied and environmental microbiology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Sukrit SilasDepartment of Pathology, Stanford University, Stanford, United States.ORCID http://orcid.org/0000-0003-3251-8579
Patricia Lucas-ElioDepartment of Genetics and Microbiology, Universidad de Murcia, Murcia, Spain.ORCID http://orcid.org/0000-0001-7182-1189
Simon A JacksonDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-4512-3093
Alejandra Aroca-CrevillénDepartment of Genetics and Microbiology, Universidad de Murcia, Murcia, Spain.
Loren L HansenDepartment of Pathology, Stanford University, Stanford, United States.
Peter C FineranDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-4639-6704
Andrew Z FireDepartment of Pathology, Stanford University, Stanford, United States.ORCID http://orcid.org/0000-0001-6217-8312
Antonio Sánchez-AmatDepartment of Genetics and Microbiology, Universidad de Murcia, Murcia, Spain.ORCID http://orcid.org/0000-0001-8597-9235
Stanford University · USUniversidad de Murcia · ESUniversity of Otago · NZ

Funding

GENE REGULATION DURING EARLY DEVELOPMENT OF C. ELEGANSR01GM037706 · NIGMS · STANFORD UNIVERSITY · PI FIRE, ANDREW Z. · 1987 to 2018
$11.0M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM037706
6 · The paper itself

Abstract

CRISPR-Cas-mediated defense utilizes information stored as spacers in CRISPR arrays to defend against genetic invaders. We define the mode of target interference and role in antiviral defense for two CRISPR-Cas systems in

Indexed as

BacteriophagesBase SequenceClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsDNA, ViralGene Transfer, HorizontalMarinomonasPlasmidsRNA, ViralType III Secretion SystemsType I Secretion SystemsDNA, ViralRNA, ViralType III Secretion SystemsType I Secretion SystemsbacteriaCRISPRevolutionary biologygenomicsimmunityinfectious diseaseMarinomonas mediterraneamicrobiologyphagephage-host arms race

Identifiers

PMID28826484
PMCPMC5576922
OpenAlexW2749415621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.