Evidence map›Paper›PMID 28826452›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2017

R R Nathavitharana, P Daru, A E Barrera, S M Mostofa Kamal, S Islam, M Ul-Alam, R Sultana, M Rahman, Md S Hossain, P Lederer and 5 more

Open access · greenAbstract read
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 8 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 8 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  3. Number needed to screen for TB in clinical, structural or occupational risk groups.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
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  20. The blueprint for prevention of nosocomial tuberculosis transmission is clear, but why don't we have the will to follow it?Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

R R NathavitharanaDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
P DaruUniversity Research Co., Washington DC.
A E BarreraFaculty of Nursing Science, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
S M Mostofa KamalNational Institute of Diseases of the Chest Hospital, Dhaka, Bangladesh.
S IslamNational Institute of Diseases of the Chest Hospital, Dhaka, Bangladesh.
M Ul-AlamNational Institute of Diseases of the Chest Hospital, Dhaka, Bangladesh.
R SultanaNational Institute of Diseases of the Chest Hospital, Dhaka, Bangladesh.
M RahmanNational Institute of Diseases of the Chest Hospital, Dhaka, Bangladesh.
Md S HossainNational Institute of Diseases of the Chest Hospital, Dhaka, Bangladesh.
P LedererDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.
S HurwitzDivision of Biostatistics, Brigham and Women's Hospital Center for Clinical Investigation, Boston, Massachusetts.
K ChakrabortyUniversity Research Co., Washington DC.
N KakUniversity Research Co., Washington DC.
D B TierneyDivision of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
E NardellDivision of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
National Institute of Cardiovascular Diseases · BDBrigham and Women's Hospital · USUniversity Research Co (United States) · USBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USUniversity of Pennsylvania · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

settingNational Institute of Diseases of the Chest and Hospital, Dhaka; Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, Dhaka; and Chittagong Chest Disease Hospital, Chittagong, Bangladesh.

objectiveTo present operational data and discuss the challenges of implementing FAST (Find cases Actively, Separate safely and Treat effectively) as a tuberculosis (TB) transmission control strategy.

designFAST was implemented sequentially at three hospitals.

resultsUsing Xpert® MTB/RIF, 733/6028 (12.2%, 95%CI 11.4-13.0) patients were diagnosed with unsuspected TB. Patients with a history of TB who were admitted with other lung diseases had more than twice the odds of being diagnosed with unsuspected TB as those with no history of TB (OR 2.6, 95%CI 2.2-3.0, P < 0.001). Unsuspected multidrug-resistant TB (MDR-TB) was diagnosed in 89/1415 patients (6.3%, 95%CI 5.1-7.7). Patients with unsuspected TB had nearly five times the odds of being diagnosed with MDR-TB than those admitted with a known TB diagnosis (OR 4.9, 95%CI 3.1-7.6, P < 0.001). Implementation challenges include staff shortages, diagnostic failure, supply-chain issues and reliance on external funding.

conclusionFAST implementation revealed a high frequency of unsuspected TB in hospitalized patients in Bangladesh. Patients with a previous history of TB have an increased risk of being diagnosed with unsuspected TB. Ensuring financial resources, stakeholder engagement and laboratory capacity are important for sustainability and scalability.

Indexed as

BangladeshHospitalizationHumansMycobacterium tuberculosisPrevalenceRifampinTuberculosisTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryRifampin

Identifiers

PMID28826452
PMCPMC5757242
OpenAlexW2746906473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.