ArticleJournal of the mechanical behavior of biomedical materials2017
Evaluation of transcatheter heart valve biomaterials: Biomechanical characterization of bovine and porcine pericardium.
Article in Journal of the mechanical behavior of biomedical materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 104 citations in OpenAlex.
- Comparative Analysis of Leaflet Materials, Stent Materials, and Stent Cell Density for Bileaflet Transcatheter Mitral Valve Design.Annals of biomedical engineering · 2026Article
- Innovation and Challenges in Materials for Transcatheter Aortic Valves.Journal of cardiovascular translational research · 2026Review
- A hybrid phenomenological finite element model of transcatheter aortic valve leaflet behaviour under non-circular annular deployment: in vitro validation and biomechanical insights.Biomechanics and modeling in mechanobiology · 2026Article
- Anisotropic hyperelastic properties of porcine pericardium under equibiaxial loading: implications for aortic valve design.Frontiers in bioengineering and biotechnology · 2026Article
- Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials.Journal of the American Heart Association · 2025Review
- Review of Machine Learning Techniques in Soft Tissue Biomechanics and Biomaterials.Cardiovascular engineering and technology · 2024Review
- A parametric study regarding structural design of a bioprosthetic aortic valve by 3D fluid-structure interaction simulations.Heliyon · 2024Article
- Analysis of fibrocalcific aortic valve stenosis: computational pre-and-post TAVR haemodynamics behaviours.Royal Society open science · 2024Article
- Parameterization, algorithmic modeling, and fluid-structure interaction analysis for generative design of transcatheter aortic valves.Engineering with computers · 2024Article
- Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling.Journal of biomaterials applications · 2023Review
- Calcification of Various Bioprosthetic Materials in Rats: Is It Really Different?International journal of molecular sciences · 2023Article
- Designing a Novel Asymmetric Transcatheter Aortic Valve for Stenotic Bicuspid Aortic Valves Using Patient-Specific Computational Modeling.Annals of biomedical engineering · 2023Article
- Technical Aspects and Development of Transcatheter Aortic Valve Implantation.Journal of cardiovascular development and disease · 2022Review
- Current Prostheses for Transcatheter Heart Valve Replacement: A Technical and Clinical Review.Reviews in cardiovascular medicine · 2022Review
- [Comparative study on Sichuan yak pericardium and Australian cattle pericardium].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Biological Equivalence of GGTA-1 Glycosyltransferase Knockout and Standard Porcine Pericardial Tissue Using 90-Day Mitral Valve Implantation in Adolescent Sheep.Cardiovascular engineering and technology · 2022Article
- Risky interpretations across the length scales: continuum vs. discrete models for soft tissue mechanobiology.Biomechanics and modeling in mechanobiology · 2022Article
- Effects of membrane and flexural stiffnesses on aortic valve dynamics: identifying the mechanics of leaflet flutter in thinner biological tissues.Forces in mechanics · 2022Article
- A Novel Crosslinking Method for Improving the Anti-Calcification Ability and Extracellular Matrix Stability in Transcatheter Heart Valves.Frontiers in bioengineering and biotechnology · 2022Article
- A Biohybrid Material With Extracellular Matrix Core and Polymeric Coating as a Cell Honing Cardiovascular Tissue Substitute.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveBovine pericardium (BP) has been identified as a choice biomaterial for the development of surgical bioprosthetic heart valves (BHV) and transcatheter aortic valves (TAV). Porcine pericardium (PP) and younger BP have been suggested as candidates TAV leaflet biomaterials for smaller-profile devices due to their reduced thickness; however, their mechanical and structural properties remain to be fully characterized. This study characterized the material properties of chemically treated thick (PPK) and thin (PPN) PP, as well as fetal (FBP), calf (CBP) and adult (ABP) BP tissues in order to better understand their mechanical behavior.
methodsPlanar biaxial testing and uniaxial failure testing methods were employed to quantify tissue mechanical responses and failure properties. Fiber characteristics were examined using histological analysis.
resultsABP and CBP tissues were significantly stiffer and stronger than the younger FBP tissues. Histological analysis revealed a significantly larger concentration of thin immature collagen fibers in the FBP tissues than in the ABP and CBP tissues. While PP tissues were thinnest, they were stiffer and less extensible than the BP tissues.
conclusionsDue to comparable mechanical properties but significantly reduced thickness, CBP tissue may be a more suitable material for TAV manufacturing than ABP tissue. FBP tissue, despite its reduced thickness and higher flexibility, was weaker and should be studied in more detail. Although PP tissues are the thinnest, they were least extensible and failed at earlier strain than BP tissues. The differences between PP and BP tissues should be further investigated and suggest that they should not be used interchangeably in the manufacturing of TAV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.