ArticleJournal of affective disorders2018
Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- Effects of working memory and reward reactivity on externalizing behaviors in the ABCD study.Developmental cognitive neuroscience · 2026Article
- Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression.Molecular psychiatry · 2026Article
- Sex differences in brain activity and connectivity in late-life depression.Psychoradiology · 2026Article
- Exploring the impact of biological sex on intrinsic connectivity networks in PTSD: A data-driven approach.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- The role of gender factors influencing multiple dimensions of somatic symptoms in major depressive disorder patients with suicidal ideation: insights from the Chinese NSSD study.BMC psychiatry · 2024Article
- Characteristics of healthy Japanese young adults with respect to recognition of facial expressions: a preliminary study.BMC psychology · 2023Article
- Neural reactivity to neutral and aversive stimuli: Evidence for altered precuneus function in internalizing psychopathologies.Psychiatry research. Neuroimaging · 2023Article
- Sex differences in residual somatic symptoms in patients with first-episode depression after acute-phase treatment.BMC psychiatry · 2023Article
- FMRI study of implicit emotional face processing in patients with MDD with melancholic subtype.Frontiers in human neuroscience · 2023Article
- Human emotion processing accuracy, negative biases, and fMRI activation are associated with childhood trauma.Frontiers in psychiatry · 2023Article
- Recognition of masked and unmasked facial expressions in males and females and relations with mental wellness.Frontiers in psychology · 2023Article
- The characteristics of brain network in patient with post-stroke depression under cognitive task condition.Frontiers in neuroscience · 2023Article
- A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder.Brain sciences · 2022Article
- Increased sensitivity of insula to supraliminal faces in adults with histories of mood disorders and self-injury.Journal of psychiatric research · 2022Article
- Disrupted intrinsic functional brain topology in patients with major depressive disorder.Molecular psychiatry · 2021Article
- Sexual Dimorphism in the Brain Correlates of Adult-Onset Depression: A Pilot Structural and Functional 3T MRI Study.Frontiers in psychiatry · 2021Article
- Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study.Frontiers in aging neuroscience · 2021Article
- Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABAFrontiers in medicine · 2020Review
- Neural response to emotional faces in monozygotic twins: association with familial risk of affective disordersJournal of psychiatry & neuroscience : JPN · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSex differences in emotion processing may play a role in women's increased risk for Major Depressive Disorder (MDD). However, studies of sex differences in brain mechanisms involved in emotion processing in MDD (or interactions of sex and diagnosis) are sparse.
methodsWe conducted an event-related fMRI study examining the interactive and distinct effects of sex and MDD on neural activity during a facial emotion perception task. To minimize effects of current affective state and cumulative disease burden, we studied participants with remitted MDD (rMDD) who were early in the course of the illness. In total, 88 individuals aged 18-23 participated, including 48 with rMDD (32 female) and 40 healthy controls (HC; 25 female).
resultsfMRI revealed an interaction between sex and diagnosis for sad and neutral facial expressions in the superior frontal gyrus and left middle temporal gyrus. Results also revealed an interaction of sex with diagnosis in the amygdala. LIMITATIONS: Data was from two sites, which might increase variability, but it also increases power to examine sex by diagnosis interactions.
conclusionsThis study demonstrates the importance of taking sex differences into account when examining potential trait (or scar) mechanisms that could be useful in identifying individuals at-risk for MDD as well as for evaluating potential therapeutic innovations.
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