Evidence map›Paper›PMID 28825718›Full record

ArticleNature neuroscience2017

Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells.

Jiangteng Lu, Jason Tucciarone, Nancy Padilla-Coreano, Miao He, Joshua A Gordon, Z Josh Huang

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Cortical control of chandelier cells in neural codes.Frontiers in cellular neuroscience · 2022
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Highly Localized Interaction between Neurofascin-186 and Gliomedin Promotes Subcellular Innervation by the Chandelier Cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  9. Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Cell Type-Specific Alterations in Excitability and Inhibition of Upper Motor Neurons in AlsinKO Mice, a Model of Juvenile Onset ALS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jiangteng LuCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Jason TucciaroneCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Nancy Padilla-CoreanoDepartments of Neuroscience and Psychiatry, Columbia University, New York, New York, USA.
Miao HeCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Joshua A GordonDepartments of Neuroscience and Psychiatry, Columbia University, New York, New York, USA.
Z Josh HuangCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.ORCID http://orcid.org/0000-0003-0592-028X
Cold Spring Harbor Laboratory · USFudan University · CNColumbia University · US

Funding

Genetic analysis of chandelier cells during cortical circuit assemblyR01MH094705 · NIMH · DUKE UNIVERSITY · PI HUANG, Z JOSH · 2011 to 2022
$5.8M
Neural mechanisms of increased anxiety in serotonin 1A receptor-deficient miceR01MH081968 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONARDO, EDUARDO DAVID · 2008 to 2017
$3.7M
Mapping the Inputs onto Neocortical Chandelier CellsF30MH097425 · NIMH · COLD SPRING HARBOR LABORATORY · PI TUCCIARONE, JASON M · 2012 to 2014
$77k
Intramural NIH HHS Z99 MH999999NIMH NIH HHS F30 MH097425NIMH NIH HHS R01 MH081968NIMH NIH HHS R01 MH094705
6 · The paper itself

Abstract

The neocortex comprises multiple information processing streams mediated by subsets of glutamatergic pyramidal cells (PCs) that receive diverse inputs and project to distinct targets. How GABAergic interneurons regulate the segregation and communication among intermingled PC subsets that contribute to separate brain networks remains unclear. Here we demonstrate that a subset of GABAergic chandelier cells (ChCs) in the prelimbic cortex, which innervate PCs at spike initiation site, selectively control PCs projecting to the basolateral amygdala (

Indexed as

AnimalsBasolateral Nuclear ComplexFemaleGABAergic NeuronsInterneuronsMaleMiceNeocortexNeural InhibitionNeural PathwaysPrefrontal CortexPyramidal Cells

Identifiers

PMID28825718
PMCPMC5614838
OpenAlexW2951384183

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.