Evidence map›Paper›PMID 28825710›Full record

ArticleNature chemical biology2017

Metals induce transient folding and activation of the twister ribozyme.

Subrata Panja, Boyang Hua, Diego Zegarra, Taekjip Ha, Sarah A Woodson

Open access · greenAbstract read
In one paragraph

Article in Nature chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Competition for Hfq drives kinetic selection of mRNA targets byProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. FRET-guided modeling of nucleic acids.Nucleic acids research · 2024
    Article
  10. Article
  11. Influence of MgACS omega · 2023
    Article
  12. Article
  13. Article
  14. Contributions and competition of MgRNA (New York, N.Y.) · 2020
    Article
  15. Article
  16. Light-controlled twister ribozyme with single-molecule detection resolves RNA function in time and space.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. RNA Droplets.Annual review of biophysics · 2020
    Review
  18. MgBiophysical journal · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Subrata PanjaT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA.
Boyang HuaDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0002-8869-9762
Diego ZegarraT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA.
Taekjip HaT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0003-2195-6258
Sarah A WoodsonT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0003-0170-1987
Johns Hopkins University · USHoward Hughes Medical Institute · US

Funding

Single Molecule Study of Helicase MechanismsR01GM065367 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HA, TAEKJIP · 2002 to 2014
$3.6M
Acquisition of Sony Biotechnology iCyt Synergy SY3200 BSC Cell SorterS10OD016230 · OD · JOHNS HOPKINS UNIVERSITY · PI MCCAFFERY, J. MICHAEL · 2014 to 2014
$520k
NIGMS NIH HHS R01 GM065367NIH HHS S10 OD016230
6 · The paper itself

Abstract

Twister is a small ribozyme present in almost all kingdoms of life that rapidly self-cleaves in variety of divalent metal ions. We used activity assays, bulk FRET and single-molecule FRET (smFRET) to understand how different metal ions promote folding and self-cleavage of the Oryza sativa twister ribozyme. Although most ribozymes require additional Mg

Indexed as

Enzyme ActivationFluorescence Resonance Energy TransferMagnesiumNucleic Acid ConformationOryzaRNA, CatalyticZincMagnesiumRNA, CatalyticZinc

Identifiers

PMID28825710
PMCPMC5605428
OpenAlexW2746298814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.