ArticleNature immunology2017
Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver.
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries.Nature cardiovascular research · 2026Article
- Thymus Ontogeny and Development.Advances in experimental medicine and biology · 2025Review
- Ever-evolving insights into the cellular and molecular drivers of lymphoid cell development.Experimental hematology · 2024Review
- Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation.iScience · 2023Article
- Speed and navigation control of thymocyte development by the fetal T-cell gene regulatory network.Immunological reviews · 2023Review
- Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells.Frontiers in immunology · 2023Review
- The EHA Research Roadmap: Normal Hematopoiesis.HemaSphere · 2021Article
- Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.Cell research · 2021Article
- Lymphoid Tissue inducer (LTi) cell ontogeny and functioning in embryo and adult.Biomedical journal · 2021Review
- The Notch signaling pathway involvement in innate lymphoid cell biology.Biomedical journal · 2021Review
- Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human.Experimental hematology · 2021Review
- Article
- A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics.Nature immunology · 2020Article
- Hematopoiesis: A Layered Organization Across Chordate Species.Frontiers in cell and developmental biology · 2020Review
- Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Development.Frontiers in cell and developmental biology · 2020Review
- The influence of space and time on the establishment of B cell identity.Biomedical journal · 2019Review
- Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Transcriptional Regulation in the Immune System: One Cell at a Time.Frontiers in immunology · 2019Review
- Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular events that initiate lymphoid-lineage specification remain unidentified because the stages of differentiation during which lineage commitment occurs are difficult to characterize. We isolated fetal liver progenitor cells undergoing restriction of their differentiation potential toward the T cell-innate lymphoid cell lineage or the B cell lineage. Transcripts that defined the molecular signatures of these two subsets were sequentially upregulated in lympho-myeloid precursor cells and in common lymphoid progenitor cells, respectively, and this preceded lineage restriction; this indicates that T cell-versus-B cell commitment is not a binary fate 'decision'. The T cell-bias and B cell-bias transcriptional programs were frequently co-expressed in common lymphoid progenitor cells and were segregated in subsets biased toward T cell differentiation or B cell differentiation, after interleukin 7 (IL-7) signaling that controlled the number of progenitor cells engaging in T cell differentiation versus B cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.