ArticleInternational journal of molecular sciences2017
Protocatechuic Acid from Pear Inhibits Melanogenesis in Melanoma Cells.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Mechanistic Insights into Anti-Melanogenic Effects of Fisetin: PKCα-Induced β-Catenin Degradation, ERK/MITF Inhibition, and Direct Tyrosinase Suppression.International journal of molecular sciences · 2025Article
- Anti-melanogenic effects of Medicago sativa seed extracts on melanocytes.International journal of cosmetic science · 2025Article
- Inhibition of α-Glucosidase Activity and Islet Amyloid PolyPeptide Fibril Formation byPlants (Basel, Switzerland) · 2025Article
- The extract of dendrobium Coelonin inhibits PIH induced by AFR COPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Upcycled Cocoa Pod Husk: A Sustainable Source of Phenol and Polyphenol Ingredients for Skin Hydration, Whitening, and Anti-Aging.Life (Basel, Switzerland) · 2025Article
- Anti-melanogenic effects of hydroxyethyl chrysin through the inhibition of tyrosinase activity:Heliyon · 2025Article
- Phytochemicals of nutraceutical importance from different pear cultivars in the early stage of development.Food chemistry: X · 2024Article
- The Effect of Maturity Stage on Polyphenolic Composition, Antioxidant and Anti-Tyrosinase Activities ofAntioxidants (Basel, Switzerland) · 2024Article
- Anti-Melanogenic and Anti-Inflammatory Effects of 2'-Hydroxy-4',6'-dimethoxychalcone in B16F10 and RAW264.7 Cells.Current issues in molecular biology · 2024Article
- The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review.Molecules (Basel, Switzerland) · 2024Review
- Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells.Journal of cancer prevention · 2023Article
- SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells.International journal of molecular sciences · 2022Article
- Cinnamomi Ramulus inhibits the growth of colon cancer cells via Akt/ERK signaling pathways.Chinese medicine · 2022Article
- Cajanin Suppresses Melanin Synthesis through Modulating MITF in Human Melanin-Producing Cells.Molecules (Basel, Switzerland) · 2021Article
- A review of pears (Pyrus spp.), ancient functional food for modern times.BMC complementary medicine and therapies · 2021Review
- Propionic acid produced by Cutibacterium acnes fermentation ameliorates ultraviolet B-induced melanin synthesis.Scientific reports · 2021Article
- Evaluation of Antioxidant and Enzyme Inhibition Properties ofMolecules (Basel, Switzerland) · 2021Article
- A Comparative Investigation on Phenolic Composition, Characterization and Antioxidant Potentials of Five Different Australian Grown Pear Varieties.Antioxidants (Basel, Switzerland) · 2021Article
- Natural skin-whitening compounds for the treatment of melanogenesis (Review).Experimental and therapeutic medicine · 2020Article
- Germinated Riceberry Rice Enhanced Protocatechuic Acid and Vanillic Acid to Suppress Melanogenesis through Cellular Oxidant-Related Tyrosinase Activity in B16 Cells.Antioxidants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component, protocatechuic acid (PCA), on melanogenesis in mouse melanoma cells. We found that PE and PCA significantly suppressed melanin content and cellular tyrosinase activity through a decrease in the expression of melanogenic enzymes and microphthalmia-associated transcription factor (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.