ArticleNanomaterials (Basel, Switzerland)2017
Two-in-One Biointerfaces-Antimicrobial and Bioactive Nanoporous Gallium Titanate Layers for Titanium Implants.
Article in Nanomaterials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 61 citations in OpenAlex.
- The dental implant surface: a review of the past, present and future.Journal of materials science. Materials in medicine · 2026Review
- Antibacterial Properties and Biocompatibility of Multicomponent Titanium Oxides: A Review.Materials (Basel, Switzerland) · 2024Review
- Antimicrobial Effects of Metal Coatings or Physical, Chemical Modifications of Titanium Dental Implant Surfaces for Prevention of Peri-Implantitis: A Systematic Review of In Vivo Studies.Antibiotics (Basel, Switzerland) · 2024Review
- Development of Novel Antibacterial Ti-Nb-Ga Alloys with Low Stiffness for Medical Implant Applications.Journal of functional biomaterials · 2024Article
- Gallium-Containing Materials and Their Potential within New-Generation Titanium Alloys for Biomedical Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Synthesis of Antimicrobial Gallium Nanoparticles Using the Hot Injection Method.ACS materials Au · 2023Article
- Dual-Action Effect of Gallium and Silver Providing Osseointegration and Antibacterial Properties to Calcium Titanate Coatings on Porous Titanium Implants.International journal of molecular sciences · 2023Article
- Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties.Bioactive materials · 2022Review
- Recent advances in prevention, detection and treatment in prosthetic joint infections of bioactive materials.Frontiers in bioengineering and biotechnology · 2022Review
- Extracellular-Vesicle-Based Coatings Enhance Bioactivity of Titanium Implants-SurfEV.Nanomaterials (Basel, Switzerland) · 2021Article
- The Use of Simulated Body Fluid (SBF) for Assessing Materials Bioactivity in the Context of Tissue Engineering: Review and Challenges.Biomimetics (Basel, Switzerland) · 2020Review
- Antibacterial Properties of Triethoxysilylpropyl Succinic Anhydride Silane (TESPSA) on Titanium Dental Implants.Polymers · 2020Article
- Antimicrobial and Osseointegration Properties of Nanostructured Titanium Orthopaedic Implants.Materials (Basel, Switzerland) · 2017Review
- Improved bioactivity of GUMMETALJournal of tissue engineeringArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitory effect of gallium (Ga) ions on bone resorption and their superior microbial activity are attractive and sought-after features for the vast majority of implantable devices, in particular for implants used for hard tissue. In our work, for the first time, Ga ions were successfully incorporated into the surface of titanium metal (Ti) by simple and cost-effective chemical and heat treatments. Ti samples were initially treated in NaOH solution to produce a nanostructured sodium hydrogen titanate layer approximately 1 μm thick. When the metal was subsequently soaked in a mixed solution of CaCl₂ and GaCl₃, its Na ions were replaced with Ca and Ga ions in a Ga/Ca ratio range of 0.09 to 2.33. 8.0% of the Ga ions were incorporated into the metal surface when the metal was soaked in a single solution of GaCl₃ after the NaOH treatment. The metal was then heat-treated at 600 °C to form Ga-containing calcium titanate (Ga-CT) or gallium titanate (GT), anatase and rutile on its surface. The metal with Ga-CT formed bone-like apatite in a simulated body fluid (SBF) within 3 days, but released only 0.23 ppm of the Ga ions in a phosphate-buffered saline (PBS) over a period of 14 days. In contrast, Ti with GT did not form apatite in SBF, but released 2.96 ppm of Ga ions in PBS. Subsequent soaking in hot water at 80 °C dramatically enhanced apatite formation of the metal by increasing the release of Ga ions up to 3.75 ppm. The treated metal exhibited very high antibacterial activity against multidrug resistant
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.