Evidence map›Paper›PMID 28825498›Full record

Trial reportHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2017

Evaluation of coping as a mediator of the relationship between stressful life events and cancer-related distress.

Dale J Langford, Bruce Cooper, Steven Paul, Janice Humphreys, Carolyn Keagy, Yvette P Conley, Marilyn J Hammer, Jon D Levine, Fay Wright, Michelle Melisko and 2 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Associations of personality profiles with stress and resilience characteristics among patients undergoing cancer chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational
  3. Article
  4. Article
  5. Coping with cancer and a history of health-related events.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023
    Article
  6. Article
  7. Article
  8. The relations between discrimination, stressful life events, and substance use among adults experiencing homelessness.Stress and health : journal of the International Society for the Investigation of Stress · 2022
    Article
  9. Article
  10. Comorbidity, Functional Impairment, and Emotional Distress: A Coping Mediation Model for Persons With Cancer.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021
    Article
  11. Article
  12. Adaptive and maladaptive forms of disengagement coping in caregivers of children with chronic illnesses.Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Article
  13. Review
  14. Article
  15. Higher levels of stress and different coping strategies are associated with greater morning and evening fatigue severity in oncology patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Dale J LangfordSchool of Nursing, University of California, San Francisco.
Bruce CooperSchool of Nursing, University of California, San Francisco.
Steven PaulSchool of Nursing, University of California, San Francisco.
Janice HumphreysSchool of Nursing, Duke University.
Carolyn KeagyKaiser Permanente.
Yvette P ConleySchool of Nursing, University of Pittsburgh.
Marilyn J HammerCollege of Nursing, New York University.
Jon D LevineSchool of Dentistry, University of California, San Francisco.
Fay WrightSchool of Nursing, Yale University.
Michelle MeliskoDepartment of Medicine, University of California, San Francisco.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco.
Laura B DunnDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University.
University of California, San Francisco · USDuke University · USKaiser Permanente · USNew York University · USStanford University · USUniversity of Pittsburgh · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
Symptom Management After Breast Cancer SurgeryR01CA107091 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2003 to 2008
$4.5M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA107091NCI NIH HHS R01 CA134900
6 · The paper itself

Abstract

objectiveLifetime stressful life events (SLEs) may predispose oncology patients to cancer-related distress (i.e., intrusive thoughts, hyperarousal, avoidance). Coping may influence cancer-related distress by mediating this relationship. This study sought to (a) determine the prevalence and impact of lifetime SLEs among oncology outpatients receiving chemotherapy and (b) examine the relationship between SLEs and cancer-related distress and the mediating role of coping on this relationship.

methodPatients (n = 957), with breast, gastrointestinal, gynecologic or lung cancer, who were undergoing chemotherapy, completed the Life Stressor Checklist-Revised (LSC-R), a measure of lifetime SLEs. Cancer-related distress was assessed with the Impact of Event Scale-Revised. Coping strategies since beginning chemotherapy were assessed with the Brief COPE; 2 latent variables (engagement and disengagement coping) were identified based on these scores. LSC-R scores (number of SLEs and perceived impact during the prior year) were evaluated in relation to demographic and clinical characteristics. Structural equation modeling was used to evaluate the relationship between LSC-R and Impact of Event Scale-Revised scores and the mediating role of engagement and disengagement coping on this relationship.

resultsOn average, patients reported 6.1 (SD = 4.0; range = 0-23 out of 30) SLEs. Patients who were not married/partnered, had incomes <$30,000/year, or who had lower functional status or greater comorbidity had higher LSC-R scores. The relationship between more SLEs and more severe cancer-related distress was completely mediated by disengagement coping. Engagement coping did not mediate this relationship.

conclusionsDisengagement coping, including behavioral disengagement, avoidance, and denial, should be targeted to mitigate cancer-related distress. (PsycINFO Database Record

Indexed as

FemaleHumansLife Change EventsMaleMiddle AgedNeoplasmsPrevalenceStress, PsychologicalSurvival Analysis

Identifiers

PMID28825498
PMCPMC5712475
OpenAlexW2748656938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.