ArticleBrain connectivity2017
Effects of Tissue-Specific Functional Magnetic Resonance Imaging Signal Regression on Resting-State Functional Connectivity.
Article in Brain connectivity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A decade of test-retest reliability of functional connectivity: A systematic review and meta-analysis.NeuroImage · 2019Pooled it
- Early Life Resting-State Network Functional Connectivity and Long-Term Neurodevelopmental Outcomes after Neonatal Encephalopathy.AJNR. American journal of neuroradiology · 2026Article
- Spatiotemporal Characterization of the Functional MRI Latency Structure with Respect to Neural Signaling and Brain Hierarchy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes.Nature communications · 2025Article
- Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Integrating Multimodal Neuroimaging and Genetics: A Structurally-Linked Sparse Canonical Correlation Analysis Approach.IEEE journal of translational engineering in health and medicine · 2024Article
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- Article
- NeoRS: A Neonatal Resting State fMRI Data Preprocessing Pipeline.Frontiers in neuroinformatics · 2022Article
- Structural Connectivity Gradients of the Temporal Lobe Serve as Multiscale Axes of Brain Organization and Cortical Evolution.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Article
- Microstructural and functional gradients are increasingly dissociated in transmodal cortices.PLoS biology · 2019Article
- Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb.NeuroImage · 2018Article
- Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.Translational psychiatry · 2018Review
- Detection of synchronous brain activity in white matter tracts at rest and under functional loading.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain.Neural plasticity · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Neuroimaging studies typically consider white matter as unchanging in different neural and metabolic states. However, a recent study demonstrated that white matter signal regression (WMSR) produced a similar loss of neurometabolic information to global (whole-brain) signal regression (GSR) in resting-state functional magnetic resonance imaging (R-fMRI) data. This was unexpected as the loss of information would normally be attributed to neural activity within gray matter correlating with the global R-fMRI signal. Indeed, WMSR has been suggested as an alternative to avoid such pitfalls in GSR. To address these concerns about tissue-specific regression in R-fMRI data analysis, we performed GSR, WMSR, and gray matter signal regression (GMSR) on R-fMRI data from the 1000 Functional Connectomes Project. We describe several regional and motion-related differences between different types of regressions. However, the overall effects of concern, particularly network-specific alteration of correlation coefficients, are present for all regressions. This suggests that tissue-specific regression is not an adequate strategy to counter pitfalls of GSR. Conversely, if GSR is desired, but the studied disease state excludes either gray matter or white matter from analysis (e.g., due to tissue atrophy), our results indicate that WMSR or GMSR may reproduce the gross effects of GSR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.