ArticleTranslational stroke research2018
Angiographic Microcirculatory Obstructions Distal to Occlusion Signify Poor Outcome after Endovascular Treatment for Acute Ischemic Stroke.
Article in Translational stroke research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Systematic review and meta-analysis on outcome differences among patients with TICI2b versus TICI3 reperfusions: success revisited.Journal of neurology, neurosurgery, and psychiatry · 2018Pooled it
- Adjunct Thrombolysis Enhances Brain Reperfusion following Successful Thrombectomy.Annals of neurology · 2022Trial
- Relevance of persistent perfusion deficits on clinical outcomes after successful endovascular treatment: a prospective serial magnetic resonance study.Frontiers in neurology · 2025Article
- Incomplete reperfusion and the presence of distal emboli in predicting clinical outcome after endovascular thrombectomy.BMJ surgery, interventions, & health technologies · 2025Article
- Inhibition of PCSK9 Protects against Cerebral Ischemia‒Reperfusion Injury via Attenuating Microcirculatory Dysfunction.Neurochemical research · 2024Article
- Implications of Post-recanalization Perfusion Deficit After Acute Ischemic Stroke: a Scoping Review of Clinical and Preclinical Imaging Studies.Translational stroke research · 2024Article
- Construction and imaging of a neurovascular unit model.Neural regeneration research · 2022Review
- Review
- β2 glycoprotein I participates in phagocytosis of apoptotic neurons and in vascular injury in experimental brain stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- TissueJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Multiphase adjuvant neuroprotection: A novel paradigm for improving acute ischemic stroke outcomes.Brain circulationReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The success of endovascular therapies depends on a number of factors including flow dynamics proximal and distal to the occlusion. The evaluation of antegrade flow distal to the occluded segment is currently a readily available, yet unexplored, option during stentriever-mediated thrombectomy. In this study, we retrospectively evaluated presence of contrast stasis and absence of capillary blush on angiograms obtained by selective injections into the distal site of occlusive thrombi, prior to deployment of stentrievers, in patients undergoing endovascular treatment for acute MCA occlusion. The role of this novel angiographic strategy assessing distal antegrade flow in predicting procedural and clinical outcome was compared to previously defined, prognostic angiographic characteristics. A total of 7 (21%) out of 34 patients had contrast stasis and lack of capillary blush downstream to the injection site. None of these patients with angiographic features suggestive of microcirculatory obstructions achieved a satisfactory outcome in terms of reperfusion (TICI grade 2B-C) and clinical outcome (90-day mRS 0-2), while the corresponding figures were 78% (p < 0.001) and 48% (p = 0.029), respectively, among patients with substantial capillary filling. These findings highlight the potentially detrimental impact of impaired microcirculatory flow on tissue and clinical outcome after recanalization/reperfusion efforts in acute ischemic stroke.
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Registered trials
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