ArticleJournal of cancer research and clinical oncology2017
Can complementary medicine increase adherence to chemotherapy dosing protocol? A controlled study in an integrative oncology setting.
Article in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Integrative oncology for young adults with cancer: A prospective pragmatic controlled trial.Medical oncology (Northwood, London, England) · 2026Trial
- Trial
- A randomized-controlled trial assessing the effect of intraoperative acupuncture on anesthesia-related parameters during gynecological oncology surgery.Journal of cancer research and clinical oncology · 2023Trial
- Effects of a patient-tailored integrative oncology intervention in the relief of pain in palliative and supportive cancer care.Journal of cancer research and clinical oncology · 2021Trial
- Traditional and Complementary Medicine Use among Cancer Patients in Asian Countries: A Systematic Review and Meta-Analysis.Cancers · 2024Review
- Cross-Cultural Patient Counseling and Communication in the Integrative Medicine Setting: Respecting the Patient's Health Belief Model of Care.Current psychiatry reports · 2024Review
- Knowledge and attitudes towards medicinal cannabis and complementary and integrative medicine (CIM): a survey of healthcare professionals working in a cancer hospital in Australia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Can integrative oncology increase adherence to chemotherapy in advanced gynecologic cancer?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Correlation between an integrative oncology treatment program and survival in patients with advanced gynecological cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Dietary supplement use in ambulatory cancer patients: a survey on prevalence, motivation and attitudes.Journal of cancer research and clinical oncology · 2021Article
- Contributing to Global Health: Development of a Consensus-Based Whole Systems Research Strategy for Anthroposophic Medicine.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Inverse relationship between reduced fatigue and severity of anemia in oncology patients treated with integrative medicine: understanding the paradox.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Refugees in Conflict: Creating a Bridge Between Traditional and Conventional Health Belief Models.The oncologist · 2018Article
- Effects of Nonpharmacological Interventions in Chemotherapy-Induced Peripheral Neuropathy: An Overview of Systematic Reviews and Meta-Analyses.Integrative cancer therapiesReview
- Adherence to Integrative Care, Oncology Healthcare Utilization, Opioid Use and Hospitalization.Integrative cancer therapiesArticle
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CONTEXT AND
objectivesThe impact of complementary and integrative medicine (CIM) on adherence to chemotherapy regimens is unclear. We explored the effect of patient-tailored CIM treatments on the relative dose intensity (RDI) of chemotherapy among patients with breast and gynecological cancer.
methodsChemotherapy-treated patients with breast or gynecological cancer were referred by their oncology healthcare professional to a CIM treatment program. Adherence to integrative care (AIC) was defined as ≥4 CIM treatments, with ≤30 days between each treatment. Relative dose intensity (RDI) of chemotherapy was compared between CIM-treated patients and controls, and among adherence sub-groups.
resultsRDI was calculated for 106-treated patients (62 AIC) and 75 controls. Baseline-to-6-week RDI values were similar in both study arms, with a lower % RDI <1.0 among controls at 12 weeks (47 vs. 57.5%; P = 0.036). Adherence sub-groups had similar RDI values, though at 6 weeks, the AIC group had lower % RDI <1.0 (33.9 vs. 54.5%, P = 0.046). Total administered medication dose/planned dose was higher in the AIC group at 6 weeks for paclitaxel (82%/50%, P = 0.025) and carboplatin (87%/67%, P = 0.028), with no difference in cytoxan/adriamycin dosages.
conclusionA patient-tailored CIM program for patients with breast or gynecological cancer may be associated with a lower percentage of reduced RDI at 6 weeks, this in a sub-group of patients with higher adherence to CIM, and for specific chemotherapy agents, though this benefit did not persist after 12 weeks. Further research is needed to better understand the impact of CIM in cancer care.
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