Evidence map›Paper›PMID 28825119›Full record

ReviewCellular and molecular life sciences : CMLS2018

Coordination of cardiac rhythmic output and circadian metabolic regulation in the heart.

Paishiun Nelson Hsieh, Lilei Zhang, Mukesh Kumar Jain

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  4. Effect ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paishiun Nelson HsiehDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 2103 Cornell Road, Room 4-503, Cleveland, OH, USA.
Lilei ZhangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Mukesh Kumar JainDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 2103 Cornell Road, Room 4-503, Cleveland, OH, USA. mxj84@case.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Transcriptional regulation of cardiac pathological remodeling by REV-ERBαR01HL143067 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, LILEI · 2019 to 2023
$2.4M
Role of KLF15 in Circadian Regulation of Cardiac IschemiaK08HL123551 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ZHANG, LILEI · 2016 to 2020
$821k
Conserved transcriptional regulation of autophagy and lifespan by the Kruppel-like FactorsF30AG054237 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI HSIEH, PAISHIUN NELSON · 2016 to 2018
$145k
NHLBI NIH HHS K08 HL123551NHLBI NIH HHS R01 HL143067NIA NIH HHS F30 AG054237NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Over the course of a 24-h day, demand on the heart rises and falls with the sleep/wake cycles of the organism. Cardiac metabolism oscillates appropriately, with the relative contributions of major energy sources changing in a circadian fashion. The cardiac peripheral clock is hypothesized to drive many of these changes, yet the precise mechanisms linking the cardiac clock to metabolism remain a source of intense investigation. Here we summarize the current understanding of circadian alterations in cardiac metabolism and physiology, with an emphasis on novel findings from unbiased transcriptomic studies. Additionally, we describe progress in elucidating the links between the cardiac peripheral clock outputs and cardiac metabolism, as well as their implications for cardiac physiology.

Indexed as

Cardiovascular Physiological PhenomenaHeart RateAnimalsCircadian ClocksCircadian RhythmGene Expression RegulationHeartHumansMyocardiumCardiacCardiovascularCircadianMetabolismPeripheral clockTranscriptomics

Identifiers

PMID28825119
PMCPMC5765194

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.