Evidence map›Paper›PMID 28825118›Full record

ArticlePsychopharmacology2017

Role of intracellular Ca

Justin N Siemian, Yanyan Qiu, Yanan Zhang, Jun-Xu Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Mechanisms of imidazoline IBritish journal of pharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Justin N SiemianDepartment of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Yanyan QiuDepartment of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Yanan ZhangResearch Triangle Institute, Research Triangle Park, Durham, NC, USA.
Jun-Xu LiDepartment of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA. junxuli@buffalo.edu.ORCID http://orcid.org/0000-0001-8103-7013
University at Buffalo, State University of New York · USRTI International · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
IMIDAZOLINE I2 RECEPTORS AS TARGETS FOR THE TREATMENT OF PAINR01DA034806 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LI, JUN-XU · 2013 to 2017
$1.7M
NCATS NIH HHS UL1 TR001412NIDA NIH HHS R01 DA034806
6 · The paper itself

Abstract

rationaleRecent research has established the imidazoline I

objectiveThis study examined the effects of several inhibitors of Ca

methodsThe von Frey filament test was used to examine the antinociceptive effects of 2-BFI in complete Freund's adjuvant (CFA)-induced inflammatory pain in rats. A two-lever drug discrimination paradigm in which rats were trained to discriminate 5.6 mg/kg (intraperitoneally) 2-BFI from its vehicle was used to examine the discriminative stimulus effects of 2-BFI.

resultsThe L-type Ca

conclusionThese results indicate that the antinociceptive effects of 2-BFI involve intracellular Ca

Indexed as

AnalgesicsAnimalsBenzofuransCalcium SignalingDiscrimination LearningDose-Response Relationship, DrugImidazolesImidazoline ReceptorsInjections, IntraperitonealMalePain ThresholdRatsRats, Sprague-Dawley2-(2-benzofuranyl)-2-imidazolineAnalgesicsBenzofuransImidazolesimidazoline I1 receptorsImidazoline ReceptorsAntinociceptionCalcium channel blockerDrug discriminationImidazoline I2 receptorRats

Identifiers

PMID28825118
PMCPMC5660937
OpenAlexW2748301923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.