Evidence map›Paper›PMID 28825117›Full record

ArticlePsychopharmacology2017

The effects of buspirone on occupancy of dopamine receptors and the rat gambling task.

Patricia Di Ciano, Patrick Mc Cormick, Cristiana Stefan, Ernest Wong, Aaron Kim, Gary Remington, Bernard Le Foll

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Cerebellar Dopaminergic System.Frontiers in systems neuroscience · 2021
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Patricia Di CianoTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health (CAMH), University of Toronto, 33 Russell Street, Toronto, M5S 2S1, Canada.
Patrick Mc CormickSchizophrenia Program, CAMH, Toronto, ON, Canada.
Cristiana StefanClinical Laboratory and Diagnostic Services, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Ernest WongClinical Laboratory and Diagnostic Services, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Aaron KimTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health (CAMH), University of Toronto, 33 Russell Street, Toronto, M5S 2S1, Canada.
Gary RemingtonTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health (CAMH), University of Toronto, 33 Russell Street, Toronto, M5S 2S1, Canada.
Bernard Le FollTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health (CAMH), University of Toronto, 33 Russell Street, Toronto, M5S 2S1, Canada. bernard.lefoll@camh.ca.
Centre for Addiction and Mental Health · CAMental Health Research Canada · CASchizophrenia Society of Ontario · CAUniversity of Toronto · CA

Funding

Exploring occupancy of dopamine D3 receptor by buspirone in humans using positronR21DA033515 · NIDA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI BOILEAU, ISABELLE, LE FOLL, BERNARD · 2012 to 2013
$273k
NIDA NIH HHS R21 DA033515
6 · The paper itself

Abstract

backgroundThe dopamine D3 receptor (DRD

methodsBinding of [

resultsBuspirone occupied both the DRD

conclusionsAlthough buspirone had effects on the rGT at the dose that selectively occupied the DRD

Indexed as

Disease Models, AnimalAnimalsAnti-Anxiety AgentsBehavior, AddictiveBuspironeCerebellumChoice BehaviorCorpus StriatumDose-Response Relationship, DrugDrug RepositioningGamblingMaleRatsRats, Long-EvansRats, Sprague-DawleyReaction TimeAnti-Anxiety AgentsBuspironeReceptors, Dopamine D2Receptors, Dopamine D3Receptors, Dopamine D4DopamineOccupancyPHNOSerotonin

Identifiers

PMID28825117
OpenAlexW2748124028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.