Evidence map›Paper›PMID 28825056›Full record

ArticleCurrent research in diabetes & obesity journal2017

Impaired Cerebral Autoregulation-A Common Neurovascular Pathway in Diabetes may Play a Critical Role in Diabetes-Related Alzheimer's Disease.

Shashank Shekhar, Shaoxun Wang, Paige N Mims, Ezekiel Gonzalez-Fernandez, Chao Zhang, Xiaochen He, Catherine Y Liu, Wenshan Lv, Yangang Wang, Juebin Huang and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Current research in diabetes & obesity journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Role ofbioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Shashank ShekharDepartment of Neurology, University of Mississippi Medical Center, USA.
Shaoxun WangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, USA.
Paige N MimsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, USA.
Ezekiel Gonzalez-FernandezDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, USA.
Chao ZhangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, USA.
Xiaochen HeDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, USA.
Catherine Y LiuDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, USA.
Wenshan LvDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, USA.
Yangang WangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, China.
Juebin HuangDepartment of Neurology, University of Mississippi Medical Center, USA.
Fan FanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, USA.
University of Mississippi Medical Center · US

Funding

The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Animal model of impaired autoregulation for study of age related vascular cognitive impairmentR21AG050049 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI FAN, FAN · 2016 to 2017
$419k
NIA NIH HHS R21 AG050049NIGMS NIH HHS P20 GM104357
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the leading cause of progressive degenerative dementia. The hallmark pathological features include beta amyloid deposition and neurofibrillary tangles. There has been a strong association of AD with Diabetes (DM) based on human studies and animal experiments. The hallmark features of AD seem to have an exaggerated presence in AD with DM, especially type 2 diabetes (T2D). In addition, insulin resistance is a common feature in both diseases and as such AD has been called type 3 diabetes. Furthermore, impairment of cerebral autoregulation has been reported in both animal and human diabetic subjects. Cerebral vascular impairment has also been implicated in the pathophysiology of AD. There is an urgent need to develop animal models of AD and DM to explore the neuropathological mechanisms of these disease and utilize such models to develop treatment strategies.

Indexed as

Alzheimer’sAutoregulationDementiaDiabetesMyogenic responseRat modelT2DN

Identifiers

PMID28825056
PMCPMC5559201
OpenAlexW2753685822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.