ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Drinking motives and alcohol sensitivity mediate multidimensional genetic influences on alcohol use behaviors.Alcohol, clinical & experimental research · 2025Article
- Unique and Transdiagnostic Dimensions of Reward Functioning in Attention-Deficit/Hyperactivity Disorder and Alcohol Use Disorder Symptoms.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Article
- Sensitization-based risk for substance abuse in vulnerable individuals with ADHD: Review and re-examination of evidence.Neuroscience and biobehavioral reviews · 2022Review
- Effects of family history of substance use disorder on reward processing in adolescents with and without attention-deficit/hyperactivity disorder.Addiction biology · 2022Article
- Trajectories of state impulsivity domains before and after alcohol consumption in the naturalistic environment.Drug and alcohol dependence · 2022Article
- The longitudinal stability of fMRI activation during reward processing in adolescents and young adults.NeuroImage · 2021Article
- Do Emotion Dysregulation, Alexithymia and Personality Dimensions Explain the Association Between Attention-Deficit/Hyperactivity Disorder and Binge Eating Among Bariatric Surgery Candidates?Frontiers in psychology · 2021Article
- Translating Discoveries in Attention-Deficit/Hyperactivity Disorder Genomics to an Outpatient Child and Adolescent Psychiatric Cohort.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Polygenic Risk Score-Derived Subcortical Connectivity Mediates Attention-Deficit/Hyperactivity Disorder Diagnosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Reward-Related Brain Activity Prospectively Predicts Increases in Alcohol Use in Adolescents.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.Genes, brain, and behavior · 2019Article
- Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype-Based Approach.Schizophrenia bulletin · 2019Article
- Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Annual review of clinical psychology · 2018Review
- Working Memory and Vigilance as Multivariate Endophenotypes Related to Common Genetic Risk for Attention-Deficit/Hyperactivity Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Problem gambling and substance use in patients attending community mental health services.Journal of behavioral addictions · 2017Article
- Using Polygenic Risk Scores to Establish Endophenotypes: Considerations and Current Constraints.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
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5 authors at 3 institutions in 2 countries.
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Abstract
backgroundProblematic alcohol use in adolescence and adulthood is a common and often debilitating correlate of childhood attention-deficit/hyperactivity disorder (ADHD). Converging evidence suggests that ADHD and problematic alcohol use share a common additive genetic basis, which may be mechanistically related to reward-related brain function. In the current study, we examined whether polygenic risk for childhood ADHD is linked to problematic alcohol use in young adulthood through alterations in reward-related activity of the ventral striatum, a neural hub supporting appetitive behaviors and reinforcement learning.
methodsGenomic, neuroimaging, and self-report data were available for 404 non-Hispanic European-American participants who completed the ongoing Duke Neurogenetics Study. Polygenic risk scores for childhood ADHD were calculated based on a genome-wide association study meta-analysis conducted by the Psychiatric Genomics Consortium and tested for association with reward-related ventral striatum activity, measured using a number-guessing functional magnetic resonance imaging paradigm, and self-reported problematic alcohol use. A mediational model tested whether ventral striatum activity indirectly links polygenic risk for ADHD to problematic alcohol use.
resultsDespite having no main effect on problematic alcohol use, polygenic risk for childhood ADHD was indirectly associated with problematic alcohol use through increased reward-related ventral striatum activity.
conclusionsIndividual differences in reward-related brain function may, at least in part, mechanistically link polygenic risk for childhood ADHD to problematic alcohol use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.