Evidence map›Paper›PMID 28825042›Full record

ArticleCancer translational medicine

Novel Molecular Multilevel Targeted Antitumor Agents.

Poonam Sonawane, Young A Choi, Hetal Pandya, Denise M Herpai, Izabela Fokt, Waldemar Priebe, Waldemar Debinski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer translational medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Drug Conjugates for Targeting Eph Receptors in Glioblastoma.Pharmaceuticals (Basel, Switzerland) · 2020
    Article
  2. Receptor-Targeted Glial Brain Tumor Therapies.International journal of molecular sciences · 2018
    Review
  3. White paper on microbial anti-cancer therapy and prevention.Journal for immunotherapy of cancer · 2018
    Review
  4. When better still might not be good enough.Translational cancer research · 2017
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Poonam SonawaneDepartment of Cancer Biology, Brain Tumor Center of Excellence, Comprehensive Cancer Center of Wake Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Young A ChoiDepartment of Cancer Biology, Brain Tumor Center of Excellence, Comprehensive Cancer Center of Wake Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Hetal PandyaNational Institutes of Health, Bethesda, MD, USA.
Denise M HerpaiDepartment of Cancer Biology, Brain Tumor Center of Excellence, Comprehensive Cancer Center of Wake Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Izabela FoktMD Anderson Cancer Center, Houston, TX, USA.
Waldemar PriebeMD Anderson Cancer Center, Houston, TX, USA.
Waldemar DebinskiDepartment of Cancer Biology, Brain Tumor Center of Excellence, Comprehensive Cancer Center of Wake Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Atrium Health Wake Forest Baptist · USThe University of Texas MD Anderson Cancer Center · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
TUMOR SPECIFIC TARGET FOR THERAPEUTIC DELIVERIESR01CA074145 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEBINSKI, WALDEMAR · 1998 to 2019
$4.9M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA074145
6 · The paper itself

Abstract

A multifunctional fusion protein, IL-13.E13K-D2-NLS, effectively recognizes glioblastoma (GBM) cells and delivers its portion to the cell nucleus. IL-13.E13K-D2-NLS is composed of a cancer cell targeting ligand (IL-13.E13K), specialized cytosol translocation bacterial toxin domain 2 of

Identifiers

PMID28825042
PMCPMC5558462
OpenAlexW2622835960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.