ArticleBladder cancer (Amsterdam, Netherlands)2017
Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy.
Article in Bladder cancer (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Urothelial carcinoma of the bladder with prostatic stromal invasion and early postoperative bone metastases: a case report.Frontiers in urology · 2026Article
- Development and validation of a nomogram for predicting prostatic urethral involvement in bladder cancer.Scientific reports · 2025Article
- Clinical outcome of BCG treatment for patients with urothelial carcinoma of the prostatic urethra: Implications for early cystectomy.World journal of urology · 2025Article
- piRNAs and PIWI Proteins as Diagnostic and Prognostic Markers of Genitourinary Cancers.Biomolecules · 2022Review
- Editorial Concerning "Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy".Bladder cancer (Amsterdam, Netherlands) · 2017Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveUrothelial prostatic involvement (UPI) at the time of radical cystoprostatectomy (RCP) was found associated with worse survival outcomes by several previous reports. Our aim is to evaluate the impact of different levels of UPI on survival outcomes using a large series of male patients treated with RCP.
methodsWhole step section specimens from 995 male BCa patients were assessed for UPI defined as: no involvement vs. prostatic urethral carcinoma
resultsProstatic involvement was recorded in 307 (30.9%) patients: 28% with prostatic urethral CIS, 12% with lamina propria involvement, 13% with ductal CIS and 47% with stromal involvement. Median follow-up was 70 months. Patients with stromal involvement had a worse 5-year survival (12%) than those with prostatic urethra CIS (40%), lamina propria involvement (36%), and ductal CIS (35%). Considering predictors of prostatic involvement, multifocal tumor (Odds Ratio [OR]: 6.60,
conclusionsApproximately one third of RCP patients harbor prostatic involvement of urothelial carcinoma. While all UPI are associated with worse overall survival, stromal involvement confers the worst outcome supporting its classification as T4 in the TNM staging.
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