Evidence map›Paper›PMID 28824884›Full record

ArticleFrontiers in cellular and infection microbiology2017

Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by

Andrew J Fleetwood, Man K S Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M O'Brien-Simpson, Andrew D Cook, Andrew J Murphy, Stuart G Dashper, Eric C Reynolds and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 4 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 4 syntheses or guidelines pooled it, 196 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Host insulin resistance caused byFrontiers in cellular and infection microbiology · 2023
    Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
  8. Article
  9. Infection and immunity · 2026
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. International journal of molecular sciences · 2026
    Article
  17. Review
  18. Deciphering macrophage molecular responses toFrontiers in microbiology · 2026
    Article
  19. Review
  20. Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andrew J FleetwoodDepartment of Medicine, University of Melbourne, Royal Melbourne HospitalParkville, VIC, Australia.
Man K S LeeHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes InstituteMelbourne, VIC, Australia.
William SingletonOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, University of MelbourneVIC, Australia.
Adrian AchuthanDepartment of Medicine, University of Melbourne, Royal Melbourne HospitalParkville, VIC, Australia.
Ming-Chin LeeDepartment of Medicine, University of Melbourne, Royal Melbourne HospitalParkville, VIC, Australia.
Neil M O'Brien-SimpsonOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, University of MelbourneVIC, Australia.
Andrew D CookDepartment of Medicine, University of Melbourne, Royal Melbourne HospitalParkville, VIC, Australia.
Andrew J MurphyHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes InstituteMelbourne, VIC, Australia.
Stuart G DashperOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, University of MelbourneVIC, Australia.
Eric C ReynoldsOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, University of MelbourneVIC, Australia.
John A HamiltonDepartment of Medicine, University of Melbourne, Royal Melbourne HospitalParkville, VIC, Australia.
University of Melbourne · AUBaker Heart and Diabetes Institute · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

PyroptosisAnimalsCaspase 1CytokinesExtracellular VesiclesGene ExpressionGlycolysisHumansInflammasomesInflammationInterleukin-10Interleukin-12Interleukin-18Interleukin-1betaInterleukin-6MacrophagesCaspase 1CytokinesIL10 protein, humanIL18 protein, humanInflammasomesInterleukin-10Interleukin-12Interleukin-18Interleukin-1betaInterleukin-6Nitric OxideTNF protein, humanTumor Necrosis Factor-alphacytokines and inflammationglycolysis and oxidative phosphorylationinflammasomemacrophagesmetabolismP. gingivalispyroptosisvesicles

Identifiers

PMID28824884
PMCPMC5543041
OpenAlexW2745288128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.