Evidence map›Paper›PMID 28824877›Full record

ReviewFrontiers in cellular and infection microbiology2017

Mechanisms of Severe Mortality-Associated Bacterial Co-infections Following Influenza Virus Infection.

Leili Jia, Jing Xie, Jiangyun Zhao, Dekang Cao, Yuan Liang, Xuexin Hou, Ligui Wang, Zhenjun Li

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 126 citations in OpenAlex.

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  8. Clinical insights into mixedMicrobiology spectrum · 2025
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  10. Characterisation of nasopharyngeal colonisation byBMJ open respiratory research · 2025
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  19. Observational
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Leili JiaInstitute of Disease Control and Prevention of Chinese People's Liberation ArmyBeijing, China.
Jing XieInstitute of Disease Control and Prevention of Chinese People's Liberation ArmyBeijing, China.
Jiangyun ZhaoInstitute of Disease Control and Prevention of Chinese People's Liberation ArmyBeijing, China.
Dekang CaoCenter for Disease Control and Prevention of Chinese People's Armed Police ForcesBeijing, China.
Yuan LiangInstitute of Disease Control and Prevention of Chinese People's Liberation ArmyBeijing, China.
Xuexin HouState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionBeijing, China.
Ligui WangInstitute of Disease Control and Prevention of Chinese People's Liberation ArmyBeijing, China.
Zhenjun LiState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionBeijing, China.
Chinese Center For Disease Control and Prevention · CNChinese People's Liberation Army · CNNational Institute for Communicable Disease Control and Prevention · CNChinese People's Armed Police Force

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza virus infection remains one of the largest disease burdens on humans. Influenza-associated bacterial co-infections contribute to severe disease and mortality during pandemic and seasonal influenza episodes. The mechanisms of severe morbidity following influenza-bacteria co-infections mainly include failure of an antibacterial immune response and pathogen synergy. Moreover, failure to resume function and tolerance might be one of the main reasons for excessive mortality. In this review, recent advances in the study of mechanisms of severe disease, caused by bacterial co-infections following influenza virus pathogenesis, are summarized. Therefore, understanding the synergy between viruses and bacteria will facilitate the design of novel therapeutic approaches to prevent mortality associated with bacterial co-infections.

Indexed as

Anti-Bacterial AgentsBacteriaBacterial InfectionsBinding SitesCoinfectionHumansImmunity, InnateInfluenza, HumanMorbidityOrthomyxoviridaePandemicsAnti-Bacterial Agentsbacteriaco-infectioninfluenzamortalityresumption of functiontolerance

Identifiers

PMID28824877
PMCPMC5540941
OpenAlexW2741622086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.