Evidence map›Paper›PMID 28824870›Full record

ArticlePsoriasis (Auckland, N.Z.)

The metabolomics of psoriatic disease.

Di Yan, Ladan Afifi, Caleb Jeon, Megha Trivedi, Hsin Wen Chang, Kristina Lee, Wilson Liao

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Psoriasis (Auckland, N.Z.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04781036 (The Study of Foot-skin Microbiome and Metabolomics of Thai Naval Cadets With Pitted Keratolysis), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04781036 naunknown statusnot on this map

The Study of Foot-skin Microbiome and Metabolomics of Thai Naval Cadets With Pitted Keratolysis

TypeinterventionalSponsorMahidol UniversityRan2023 to 2024Enrolled250ConditionsMicrobial Disease, MetabolomicsArms4%Chlorhexidine
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Di YanDepartment of Dermatology, University of California-San Francisco, San Francisco, CA, USA.
Ladan AfifiDepartment of Dermatology, University of California-San Francisco, San Francisco, CA, USA.
Caleb JeonDepartment of Dermatology, University of California-San Francisco, San Francisco, CA, USA.
Megha TrivediDepartment of Dermatology, University of California-San Francisco, San Francisco, CA, USA.
Hsin Wen ChangDepartment of Dermatology, University of California-San Francisco, San Francisco, CA, USA.
Kristina LeeDepartment of Dermatology, University of California-San Francisco, San Francisco, CA, USA.
Wilson LiaoDepartment of Dermatology, University of California-San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

MHC and KIR Region Genomics in PsoriasisU01AI119125 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2015 to 2019
$3.5M
Identification of Causal Variants in PsoriasisR01AR065174 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2013 to 2016
$1.8M
NIAID NIH HHS U01 AI119125NIAMS NIH HHS R01 AR065174
6 · The paper itself

Abstract

Metabolomics is an emerging new "omics" field involving the systematic analysis of the metabolites in a biologic system. These metabolites provide a molecular snapshot of cellular activity and are thus important for understanding the functional changes in metabolic pathways that drive disease. Recently, metabolomics has been used to study the local and systemic metabolic changes in psoriasis and its cardiometabolic comorbidities. Such studies have revealed novel insights into disease pathogenesis and suggest new biochemical signatures that may be used as a marker of psoriatic disease. This review will discuss common strategies in metabolomics analysis, current findings in the metabolomics of psoriasis, and emerging trends in psoriatic metabolomics.

Indexed as

metabolitesmetabolomepsoriasispsoriatic arthritisskinurine

Identifiers

PMID28824870
PMCPMC5562362
OpenAlexW2584297375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.