Evidence map›Paper›PMID 28824739›Full record

ArticleThe EPMA journal2017

Postmenopausal breast cancer: European challenge and innovative concepts.

Ivica Smokovski, Milan Risteski, Jiri Polivka, Pavol Zubor, Katarzyna Konieczka, Vincenzo Costigliola, Olga Golubnitschaja

Abstract read
In one paragraph

Article in The EPMA journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ivica SmokovskiFaculty of Medical Sciences, University Goce Delcev Stip, Stip, Macedonia.
Milan RisteskiUniversity Clinic of Radiotherapy and Oncology, Skopje, Macedonia.
Jiri PolivkaDepartment of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Prague, Czech Republic.
Pavol ZuborDepartment of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Martin University Hospital, Martin, Slovak Republic.
Katarzyna KonieczkaDepartment of Ophthalmology, University of Basel, Basel, Switzerland.
Vincenzo CostigliolaEuropean Medical Association, EMA, Brussels, Belgium.
Olga GolubnitschajaRadiological clinic, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) epidemic is recognised now worldwide as the reality of the early twenty-first century. Increasing trends in the postmenopausal BC prevalence, even for the European countries earlier demonstrating relatively stable incidence rates of the disease, are highly alarming for the healthcare givers. This new actuality requires a substantial revision of the paradigm currently applied to the BC management and creation of highly innovative concepts. Current multi-centred study highlights new complex mechanisms of the development and progression of the postmenopausal BC. Innovative concepts are presented which argue for more effective predictive and preventive approaches well justified in view of the clusters of the symptoms analysed here and demonstrated as highly prevalent in the postmenopausal breast cancer versus BC-free individuals. Another conceptual novelty presented here is a new interpretation of the "Seed and Soil" theory of metastasis in BC. According to the new concept, the "pre-metastatic niches" ("Soil") are created by a systemic hypoxia a long time before the breast malignancy is clinically manifested.

Indexed as

Cardiovascular componentDiabetesDrug sensitivityFlammer syndromeMetastatic diseasePainPatient stratificationPostmenopausal breast cancerPredictive preventive and personalised medicineRisk factors“Seed and soil” theorySystemic hypoxia

Identifiers

PMID28824739
PMCPMC5545986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.