ArticleClinical epigenetics2017
The impact of methylation quantitative trait loci (mQTLs) on active smoking-related DNA methylation changes.
Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Association of DNA methylation in BDNF with escitalopram treatment response in depressed Chinese Han patients.European journal of clinical pharmacology · 2018Trial
- Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and longitudinal associations in the Singapore diet and healthy aging cohort.The journal of prevention of Alzheimer's disease · 2026Article
- Systematic investigation of interindividual variation of DNA methylation in human whole blood.Genome biology · 2026Article
- UBD: incorporating uncertainty in cell type proportion estimates from bulk samples to infer cell-type-specific profiles.Briefings in bioinformatics · 2026Article
- Exploring metabolomics for colorectal cancer risk prediction: evidence from the UK Biobank and ESTHER cohorts.BMC medicine · 2025Article
- HBI: a hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data.Genome biology · 2024Article
- Epigenetics Research in Evolutionary Biology: Perspectives on Timescales and Mechanisms.Molecular biology and evolution · 2024Review
- Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma.NPJ precision oncology · 2024Article
- Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits.BMC genomics · 2023Article
- Epigenetic and Genetic Population Structure is Coupled in a Marine Invertebrate.Genome biology and evolution · 2023Article
- Implication of DNA methylation during lifestyle mediated weight loss.Frontiers in endocrinology · 2023Review
- The potential of DNA methylation as a biomarker for obesity and smoking.Journal of internal medicine · 2022Review
- Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR.Epigenetics & chromatin · 2021Article
- Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer's disease.Translational psychiatry · 2021Article
- Dioxin exposure associated with fecundability and infertility in mothers and daughters of Seveso, Italy.Human reproduction (Oxford, England) · 2021Article
- Genetic Control of Human Infection with SARS-CoV-2.Russian journal of genetics · 2021Article
- Establishing a generalized polyepigenetic biomarker for tobacco smoking.Translational psychiatry · 2019Article
- Genetic-Driven Druggable Target Identification and Validation.Trends in genetics : TIG · 2018Review
- DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.Translational psychiatry · 2018Article
- Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults.Epigenetics · 2018Article
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5 authors.
Funding
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Abstract
backgroundMethylation quantitative trait loci (mQTLs) are the genetic variants that may affect the DNA methylation patterns of CpG sites. However, their roles in influencing the disturbances of smoking-related epigenetic changes have not been well established. This study was conducted to address whether mQTLs exist in the vicinity of smoking-related CpG sites (± 50 kb) and to examine their associations with smoking exposure and all-cause mortality in older adults.
resultsWe obtained DNA methylation profiles in whole blood samples by Illumina Infinium Human Methylation 450 BeadChip array of two independent subsamples of the ESTHER study (discovery set,
conclusionsOur findings clearly demonstrated that if not dealt with properly, the mQTLs might impair the power of epigenetic-based models of smoking exposure to a certain extent. In addition, such genetic variants could be the key factor to distinguish between the heritable and smoking-induced impact on epigenome disparities. These mQTLs are of special importance when DNA methylation markers measured by Illumina Infinium assay are used for any comparative population studies related to smoking-related cancers and chronic diseases.
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