Evidence map›Paper›PMID 28824731›Full record

ArticleClinical epigenetics2017

Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis.

J Guiot, I Struman, V Chavez, M Henket, M Herzog, K Scoubeau, N Hardat, B Bondue, J L Corhay, C Moermans and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

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  12. Air Pollution and Interstitial Lung Diseases: Defining Epigenomic Effects.American journal of respiratory and critical care medicine · 2020
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Exosomal Long Non-Coding RNAs in Lung Diseases.International journal of molecular sciences · 2020
    Review
  18. Review
  19. Review
  20. Association between Plasma HMGB-1 and Silicosis: A Case-Control Study.International journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

J GuiotPneumology Department, CHU Liège, Domaine universitaire du Sart-Tilman B35, 4000 Liège, Belgium.ORCID 0000-0001-7800-1730
I StrumanMolecular Angiogenesis Laboratory, GIGA R, University of Liège, B34, 1 avenue de l hospital Sart-Tilman, Liège, Belgium.
V ChavezDepartment of Clinical Hematology, CHU Sart Tilman, Liège, Belgium.
M HenketPneumology Department, CHU Liège, Domaine universitaire du Sart-Tilman B35, 4000 Liège, Belgium.
M HerzogBelgian Volition SPRL, Rue du Seminaire 20A, 5000 Namur, Belgium.
K ScoubeauBelgian Volition SPRL, Rue du Seminaire 20A, 5000 Namur, Belgium.
N HardatBelgian Volition SPRL, Rue du Seminaire 20A, 5000 Namur, Belgium.
B BonduePneumology Department, Erasme hospital, université libre de bruxelles, Belgium Route de Lennik, 808, 1070 Brussels, Belgium.
J L CorhayPneumology Department, CHU Liège, Domaine universitaire du Sart-Tilman B35, 4000 Liège, Belgium.
C MoermansPneumology Department, CHU Liège, Domaine universitaire du Sart-Tilman B35, 4000 Liège, Belgium.
R LouisPneumology Department, CHU Liège, Domaine universitaire du Sart-Tilman B35, 4000 Liège, Belgium.
University of Liège · BEVolition (Belgium) · BECentre Hospitalier Universitaire de Liège · BEUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disorder of unknown origin with a highly variable and unpredictable clinical course. Polymorphisms and environmentally induced epigenetic variations seem to determine individual susceptibility to the development of lung fibrosis.

methodsWe have studied circulating epitopes on cell-free nucleosomes (cfnucleosomes) in 50 IPF patients. We have compared untreated IPF (

resultsOur findings showed that serum levels of bound HMGB1, mH2A1.1, 5mC, H3K9Ac, and H3K27Ac were significantly lower in IPF patients than in HS (

conclusionOur observations showed that cfnucleosomes (bound HMGB1, mH2A1.1, 5mC, H3K9Ac, and H3K27Ac) might have potential as biomarkers for diagnosis and treatment response. These results deserve further validation in longitudinal cohorts.

Indexed as

5-MethylcytosineAgedAged, 80 and overBiomarkersDNA MethylationEpigenesis, GeneticFemaleHistonesHMGB1 ProteinHumansIdiopathic Pulmonary FibrosisMaleMiddle AgedNucleosomes5-MethylcytosineBiomarkersHistonesHMGB1 ProteinHMGB1 protein, humanNucleosomesBiomarkersEpigeneticIdiopathic pulmonary fibrosisInterstitial lung diseaseNucleosome modifications

Identifiers

PMID28824731
PMCPMC5558769
OpenAlexW2748985142

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.