Evidence map›Paper›PMID 28824721›Full record

ArticleTheranostics2017

Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction.

Chang Liu, Mu-Di Yao, Chao-Peng Li, Kun Shan, Hong Yang, Jia-Jian Wang, Ban Liu, Xiu-Miao Li, Jin Yao, Qin Jiang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 257 citations in OpenAlex.

  1. In-depth analysis of retinal RNA transcriptome sequencing in a rat model of hypertensive retinopathy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Emerging role of circular RNAs in diabetic retinopathy.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Circular RNAeLife · 2024
    Article
  13. Molecular mechanisms of circular RNA translation.Experimental & molecular medicine · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  18. Article
  19. Review
  20. Role of circular RNAs in lung cancer.Frontiers in genetics · 2024
    Review

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Chang LiuEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Mu-Di YaoThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Chao-Peng LiDepartment of Ophthalmology, Huai'an First People's Hospital, Nanjing Medical University, Jiangsu, China.
Kun ShanEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Hong YangThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Jia-Jian WangEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Ban LiuDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Xiu-Miao LiEye Hospital, Nanjing Medical University, Nanjing, China.
Jin YaoThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Qin JiangThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Biao YanEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Eye & ENT Hospital of Fudan University · CNNanjing Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CNHuaian First People’s Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular dysfunction is a hallmark of ischemic, cancer, and inflammatory diseases, contributing to disease progression. Circular RNAs (circRNAs) are endogenous non-coding RNAs, which have been reported to be abnormally expressed in many human diseases. In this study, we used retinal vasculature to determine the role of circular RNA in vascular dysfunction. We revealed that cZNF609 was significantly up-regulated upon high glucose and hypoxia stress

Indexed as

Gene SilencingAnimalsDiabetic RetinopathyEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsMice, Inbred C57BLNeovascularization, PathologicRetinaRNARNA, CircularRNARNA, Circularcircular RNAsdiabetic retinopathy.microRNA spongeretinopathy of prematurityvascular dysfunction

Identifiers

PMID28824721
PMCPMC5562221
OpenAlexW2735177611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.