Evidence map›Paper›PMID 28824652›Full record

ArticleFrontiers in immunology2017

Tumor Necrosis Factor (TNF) Bioactivity at the Site of an Acute Cell-Mediated Immune Response Is Preserved in Rheumatoid Arthritis Patients Responding to Anti-TNF Therapy.

Rachel Byng-Maddick, Carolin T Turner, Gabriele Pollara, Matthew Ellis, Naomi J Guppy, Lucy C K Bell, Michael R Ehrenstein, Mahdad Noursadeghi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Meta-Analysis ofFrontiers in immunology · 2019
    Pooled it
  2. Article
  3. Article
  4. Eosinophils in Rheumatoid Arthritis: A Multifaceted Role in the Pathogenesis of the Disease.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rachel Byng-MaddickDivision of Infection and Immunity, University College London, London, United Kingdom.
Carolin T TurnerDivision of Infection and Immunity, University College London, London, United Kingdom.
Gabriele PollaraDivision of Infection and Immunity, University College London, London, United Kingdom.
Matthew EllisDivision of Neuropathology, Institute of Neurology, University College London, London, United Kingdom.
Naomi J GuppyUCL Advanced Diagnostics, London, United Kingdom.
Lucy C K BellDivision of Infection and Immunity, University College London, London, United Kingdom.
Michael R EhrensteinDivision of Medicine, University College London, London, United Kingdom.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, United Kingdom.
University College London · GBNational Institute for Health Research · GB

Funding

Arthritis Research UK 20131Cancer Research UK 20256Medical Research Council MR/M003833/1
6 · The paper itself

Abstract

The impact of anti-tumor necrosis factor (TNF) therapies on inducible TNF-dependent activity in humans has never been evaluated

Indexed as

anti-tumor necrosis factorrheumatoid arthritistranscriptional profilingtuberculin skin testtumor necrosis factor

Identifiers

PMID28824652
PMCPMC5543043
OpenAlexW2743593717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.