Evidence map›Paper›PMID 28824581›Full record

ArticleFrontiers in microbiology2017

Stress-Driven Discovery of Novel Cryptic Antibiotics from a Marine Fungus

Bibi N Auckloo, Chengqian Pan, Najeeb Akhter, Bin Wu, Xiaodan Wu, Shan He

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

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  14. α-Pyrone and Sterol Constituents ofJournal of natural products · 2019
    Article
  15. Article
  16. Identification of Antifungal Targets Based on Computer Modeling.Journal of fungi (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bibi N AucklooOcean College, Zhejiang UniversityHangzhou, China.
Chengqian PanOcean College, Zhejiang UniversityHangzhou, China.
Najeeb AkhterOcean College, Zhejiang UniversityHangzhou, China.
Bin WuOcean College, Zhejiang UniversityHangzhou, China.
Xiaodan WuCenter of Analysis and Measurement, Zhejiang UniversityHangzhou, China.
Shan HeLaboratory of Marine Natural Products, School of Marine Sciences, Ningbo UniversityNingbo, China.
Zhejiang University · CNZhejiang Ocean University · CNNingbo University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Standard laboratory cultures have long been known to hinder activation of specific gene clusters which in turn hamper production of secondary metabolites with unique properties due to lack of innovation or the inability to trigger cryptic gene clusters' expression. Due to challenges related to the avoidance of the isolation of replicated metabolites, resistance-developing pathogens are to be addressed by the scientific community worldwide in order to progress with novel and potent compounds which could further be developed in the future for pharmaceutical usage. This study reports the isolation of novel cryptic antibiotics from a marine fungus

Indexed as

antibioticsmarine fungusmetal-stress strategypolyketidespectroscopic techniques

Identifiers

PMID28824581
PMCPMC5540946
OpenAlexW2742084962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.