Evidence map›Paper›PMID 28824531›Full record

ArticleFrontiers in neurology2017

Alterations in Spontaneous Brain Activity and Functional Network Reorganization following Surgery in Children with Medically Refractory Epilepsy: A Resting-State Functional Magnetic Resonance Imaging Study.

Yongxin Li, Zhen Tan, Jianping Wang, Ya Wang, Yungen Gan, Feiqiu Wen, Qian Chen, Derek Abbott, Kelvin K L Wong, Wenhua Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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  6. Resting-state functional MRI in pediatric epilepsy: a narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yongxin LiGuangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Zhen TanDepartment of Pediatric Neurosurgery, Shenzhen Children's Hospital, Shenzhen, China.
Jianping WangThe Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ya WangGuangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Yungen GanDepartment of Pediatric Neurosurgery, Shenzhen Children's Hospital, Shenzhen, China.
Feiqiu WenDepartment of Pediatric Neurosurgery, Shenzhen Children's Hospital, Shenzhen, China.
Qian ChenDepartment of Pediatric Neurosurgery, Shenzhen Children's Hospital, Shenzhen, China.
Derek AbbottCentre for Biomedical Engineering, School of Electrical and Electronic Engineering, University of Adelaide, Adelaide, SA, Australia.
Kelvin K L WongSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Wenhua HuangGuangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Shenzhen Children's Hospital · CNSouthern Medical University · CNGuangzhou Medical University · CNUniversity of Adelaide · AUWestern Sydney University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For some patients with medically refractory epilepsy (MRE), surgery is a safe and effective treatment for controlling epilepsy. However, the functional consequences of such surgery on brain activity and connectivity in children remain unknown. In the present study, we carried out a longitudinal study using resting-state functional magnetic resonance imaging in 10 children with MRE before and again at a mean of 79 days after surgery, as well as in a group of 28 healthy controls. Compared with the controls, children with epilepsy exhibited abnormalities in intrinsic activity in the thalamus, putamen, pallidum, insula, hippocampus, cerebellum, and cingulate gyrus both before and after surgery. Longitudinal analyses showed that the amplitude of low frequency fluctuations (ALFF) increased in the parietal-frontal cortex and decreased in the deep nuclei from pre- to post-surgery. The percentage changes in ALFF values in the deep nuclei were positively correlated with the age of epilepsy onset. Functional connectivity (FC) analyses demonstrated a reorganization of FC architecture after surgery. These changes in brain activity and FC after surgery might indicate that the previously disrupted functional interactions were reorganized after surgery. All these results provide preliminary evidence that the age of epilepsy onset may have some potential to predict the outcome of brain functional reorganization after surgery in children with MRE.

Indexed as

amplitude of low-frequency fluctuationchildrenfunctional connectivitymedically refractory epilepsysurgery

Identifiers

PMID28824531
PMCPMC5541057
OpenAlexW2744632202

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.