ArticleFrontiers in physiology2017
Molar Hypomineralisation: A Call to Arms for Enamel Researchers.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Diagnostic Indices for Epidemiological Assessment of Molar Incisor Hypomineralization: A Systematic Review.Calcified tissue international · 2026Pooled it
- Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses.bioRxiv : the preprint server for biology · 2026Article
- Comparative label-free quantitative proteomics of hypomineralised second primary molars (HSPM) and molar incisor hypomineralisation (MIH) reveals divergent enamel protein signatures underpinning distinct pathogenic mechanisms.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Severity and extent of hypomineralised defects located on working and balancing cusps: a comparative study between primary and permanent teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Longevity of stainless steel crowns in molar incisor hypomineralization: a systematic review.Frontiers in dental medicine · 2026Review
- Prevalence, clinical characteristics, and associated factors of molar-incisor hypomineralisation among schoolchildren: a cross-sectional study in the Vietnamese Northern provinces.Scientific reports · 2025Article
- Review
- Effect of ibuprofen on amelogenesis in Wistar rats.Journal of applied oral science : revista FOB · 2025Article
- Proteomic Analyses Discern the Developmental Inclusion of Albumin in Pig Enamel: A New Model for Human Enamel Hypomineralization.International journal of molecular sciences · 2023Article
- MIH and Dental Caries in Children: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Review
- Overexpression of ameloblastin in secretory ameloblasts results in demarcated, hypomineralized opacities in enamel.Frontiers in physiology · 2023Article
- Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection.Current osteoporosis reports · 2022Review
- A Breakthrough in Understanding the Pathogenesis of Molar Hypomineralisation: The Mineralisation-Poisoning Model.Frontiers in physiology · 2021Article
- Chemical gradients in human enamel crystallites.Nature · 2020Article
- Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikrein‑related peptidase 4 and tight junction proteins in ameloblasts.International journal of molecular medicine · 2020Article
- Tooth Enamel and its Dynamic Protein Matrix.International journal of molecular sciences · 2020Review
- Pathogenesis of Molar Hypomineralisation: Hypomineralised 6-Year Molars Contain Traces of Fetal Serum Albumin.Frontiers in physiology · 2020Article
- Pathogenesis of Molar Hypomineralisation: Aged Albumin Demarcates Chalky Regions of Hypomineralised Enamel.Frontiers in physiology · 2020Article
- Difficulties in identifying developmental defects of the enamel: a BITA study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2019Article
- Effect of antibiotics and NSAIDs on cyclooxygenase-2 in the enamel mineralization.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental dental defects (DDDs, hereafter "D3s") hold significance for scientists and practitioners from both medicine and dentistry. Although, attention has classically dwelt on three other D3s (amelogenesis imperfecta, dental fluorosis, and enamel hypoplasia), dental interest has recently swung toward Molar Hypomineralisation (MH), a prevalent condition characterised by well-delineated ("demarcated") opacities in enamel. MH imposes a significant burden on global health and has potential to become medically preventable, being linked to infantile illness. Yet even in medico-dental research communities there is only narrow awareness of this childhood problem and its link to tooth decay, and of allied research opportunities. Major knowledge gaps exist at population, case and tooth levels and salient information from enamel researchers has sometimes been omitted from clinically-oriented conclusions. From our perspective, a cross-sector translational approach is required to address these complex inadequacies effectively, with the ultimate aim of prevention. Drawing on experience with a translational research network spanning Australia and New Zealand (The D3 Group;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.