ReviewFrontiers in physiology2017
Long Distance Metabolic Regulation through Adipose-Derived Circulating Exosomal miRNAs: A Trail for RNA-Based Therapies?
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer.Cancer biology & therapy · 2025Review
- RNA signaling in skeletal muscle: the central role of microRNAs and exosomal microRNAs.Frontiers in cell and developmental biology · 2025Review
- Delivery of miR-26a-5p by Subcutaneous Adipose Tissue-Derived Extracellular Vesicles Alleviates Acute Lung Injury in Mice Through CHUK/NF-κB Pathway.International journal of nanomedicine · 2025Article
- Anti-inflammatory effects of kawakawa (Food science & nutrition · 2024Article
- AAV gene replacement therapy for treating MPS IIIC: Facilitating bystander effects via EV-mRNA cargo.Journal of extracellular vesicles · 2024Article
- miR-877-5p as a Potential Link between Triple-Negative Breast Cancer Development and Metabolic Syndrome.International journal of molecular sciences · 2023Article
- Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Milk/colostrum exosomes: A nanoplatform advancing delivery of cancer therapeutics.Cancer letters · 2023Review
- Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Plasma-derived exosomal miRNA as potential biomarker for diagnosis and prognosis of vector-borne diseases: A review.Frontiers in microbiology · 2023Review
- Nucleophosmin3 carried by small extracellular vesicles contribute to white adipose tissue browning.Journal of nanobiotechnology · 2022Article
- Adipose-Derived Circulating Exosomes Promote Protection of the Pulmonary Endothelial Barrier by Inhibiting EndMT and Oxidative Stress through Down-Regulation of the TGF-Oxidative medicine and cellular longevity · 2022Article
- Comparison of MicroRNA Profiles in Extracellular Vesicles from Small and Large Goat Follicular Fluid.Animals : an open access journal from MDPI · 2021Article
- Insights Into Exosomal Non-Coding RNAs Sorting Mechanism and Clinical Application.Frontiers in oncology · 2021Review
- Extracellular Vesicles in the Cornea: Insights from Other Tissues.Analytical cellular pathology (Amsterdam) · 2021Review
- Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?Developmental cell · 2020Review
- Inflexibility of the plasma miRNA response following a high-carbohydrate meal in overweight insulin-resistant women.Genes & nutrition · 2020Article
- The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease.Frontiers in pharmacology · 2020Review
- Extracellular Vesicles From Liver Progenitor Cells Downregulates Fibroblast Metabolic Activity and Increase the Expression of Immune-Response Related Molecules.Frontiers in cell and developmental biology · 2020Article
- Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells.Nature communications · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contribution of non-coding RNAs, such as microRNAs (miRNAs) in regulating physiological and pathological states has been intensively elucidated during last 15 years. The discovery of circulating miRNAs (cir-miRNAs) in variety of body fluids, is, however a recent focus of interest in understanding pathophysiological states of their originating cells/organs. Yet another stimulating debate that takes miRNAs to the next level is their presence in exosomes, and this is truly interesting area of research. Exosomes are cell-derived extracellular vesicles, and are naturally equipped biological vehicles that not only enable functional transfer of miRNAs between cells (horizontal transfer) but also foster inter-organ communication, presumably guided by organ specific receptors-decorated on their surface. However, understandings on inter-organ communication elicited by tissue specific exosomal-miRNA fingerprints remain elusive. Recently, Thomou et al., has discovered that adipose tissue contributes a large fraction of adipose specific exosomal-miRNA fingerprints in blood circulation. Experimental evidence emphasize adipose tissue as major depot of cir-miRNAs that sail through blood flow and reach to distal organs-primarily in the liver, where they regulate gene expression of host tissue and elicit metabolic control. This appears to be a genetic form of adipokines (endocrine factors secreted from adipose tissue). We review such offshore metabolic insults, and make an effort to address few important missing links between miRNAs processing and their incorporation into exosomes. We provide potential perspectives on how this knowledge could be steered towards RNA-based therapeutics for monitoring complex metabolic diseases and beyond.
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