Evidence map›Paper›PMID 28824430›Full record

ArticleFrontiers in pharmacology2017

Protopanaxadiol and Protopanaxatriol-Type Saponins Ameliorate Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus in High-Fat Diet/Streptozocin-Induced Mice.

Jianjun Deng, Yao Liu, Zhiguang Duan, Chenhui Zhu, Junfeng Hui, Yu Mi, Pei Ma, Xiaoxuan Ma, Daidi Fan, Haixia Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 72 citations in OpenAlex.

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  16. Hydroxy-α-sanshool isolated fromFrontiers in pharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jianjun DengShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Yao LiuShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Zhiguang DuanShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Chenhui ZhuShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Junfeng HuiShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Yu MiShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Pei MaShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Xiaoxuan MaShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Daidi FanShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Department of Food Science and Engineering, Northwest UniversityShaanxi, China.
Haixia YangDepartment of Nutrition and Food Safety, College of Public Health, Xi'an Jiaotong UniversityShaanxi, China.
Northwest University · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ginsenoside is a major active component of ginseng, which exhibits various pharmacological properties such as hepatoprotection, tumor suppression and diabetes resistance. In this study, the anti-diabetic effects of protopanaxadiol (PPD) and protopanaxatriol (PPT)-type saponins were explored and compared in high-fat diet/streptozocin-induced type 2 diabetes mellitus (T2DM) mice. Our results showed that low or high dose (50 mg/kg bodyweight or 150 mg/kg bodyweight) PPD and PPT significantly reduced fasting blood glucose, improved glucose tolerance and insulin resistance in T2DM mice. PPD and PPT also regulated serum lipid-related markers such as reduced total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol in T2DM mice. In addition, PPD and PPT dramatically ameliorated the inflammatory responses by suppressing the secretion of pro-inflammatory cytokines like tumor necrosis factor-alpha and interleukin-6 in serum level and gene expression in liver level, and improved the antioxidant capacity by increasing the superoxide dismutase and decreasing malondialdehyde levels in the serum of T2DM mice. Moreover, the anti-diabetic effect of PPD and PPT appeared to be partially mediated by the suppression of hepatic metabolism genes expression such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase, as well as facilitating lipid metabolism genes expression such as microsomal TG transfer protein in the liver tissues of T2DM mice. Taken together, our results indicated that PPD and PPT might potentially act as natural anti-diabetic compounds to be used for preventing and treating the T2DM and its complications in the future.

Indexed as

glucose metabolisminflammationlipid metabolismprotopanaxadiol-type saponinsprotopanaxatriol-type saponinstype 2 diabetes mellitus

Identifiers

PMID28824430
PMCPMC5539091
OpenAlexW2737387901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.