ArticleFrontiers in aging neuroscience2017
The Abnormality of Topological Asymmetry between Hemispheric Brain White Matter Networks in Alzheimer's Disease and Mild Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 75 citations in OpenAlex.
- Fornix Mediates Information Propagation in Brain Networks Following DLPFC-Targeted rTMS in Alzheimer's Disease: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2025Trial
- White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia.Neuroimage. Reports · 2026Article
- Hemispheric imbalance in mild cognitive impairment: a graph-theoretical analysis of multimodal brain networks.Annals of medicine · 2026Article
- Using diffusion MRI to relate hippocampal subfield microstructure to delayed verbal memory in cognitively intact individuals at genetic risk for developing Alzheimer's disease.Experimental gerontology · 2026Article
- Hemispheric disconnection as a basis for neurodegeneration in apraxia and Alzheimer's disease.Discover mental health · 2025Review
- Hemispheric asymmetries in resting-state connectivity: insights from healthy controls and implications for neurological disorders.Brain structure & function · 2025Article
- Bayesian Structural Equation Envelope Model.Psychometrika · 2025Article
- Performance of computed tomography and magnetic resonance morphometry in evaluating brain atrophy in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Socioeconomic Differences in Global Brain Asymmetry: An Integrative Approach Using Image Similarity Measures and Structural Equation Modeling.Research square · 2025Article
- Biomarker Investigation Using Multiple Brain Measures from MRI Through Explainable Artificial Intelligence in Alzheimer's Disease Classification.Bioengineering (Basel, Switzerland) · 2025Article
- Synergistic effects of GFAP and Aβ42: Implications for white matter integrity and verbal memory across the cognitive spectrum.Brain, behavior, & immunity - health · 2024Article
- Investigation of hemispheric asymmetry in Alzheimer's disease patients during resting state revealed BY fNIRS.Scientific reports · 2024Article
- Directed functional connectivity of the default-mode-network of young and older healthy subjects.Scientific reports · 2024Article
- Hemispheric coupling between structural and functional asymmetries in clinically asymptomatic carotid stenosis with cognitive impairment.Brain imaging and behavior · 2024Article
- Hippocampal connectivity and memory decline in cognitively intact APOE ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- EEG asymmetry and cognitive testing in MCI identification.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- Regional Brain Fusion: Graph Convolutional Network for Alzheimer's Disease Prediction and Analysis.Frontiers in neuroinformatics · 2022Article
- Analysis of Brain Structural Connectivity Networks and White Matter Integrity in Patients With Mild Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- Alteration in Asymmetry of White Matter Network of Parkinson's Disease.Contrast media & molecular imaging · 2022Article
- Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease.Ophthalmology science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large number of morphology-based studies have previously reported a variety of regional abnormalities in hemispheric asymmetry in Alzheimer's disease (AD). Recently, neuroimaging studies have revealed changes in the topological organization of the structural network in AD. However, little is known about the alterations in topological asymmetries. In the present study, we used diffusion tensor image tractography to construct the hemispheric brain white matter networks of 25 AD patients, 95 mild cognitive impairment (MCI) patients, and 48 normal control (NC) subjects. Graph theoretical approaches were then employed to estimate hemispheric topological properties. Rightward asymmetry in both global and local network efficiencies were observed between the two hemispheres only in AD patients. The brain regions/nodes exhibiting increased rightward asymmetry in both AD and MCI patients were primarily located in the parahippocampal gyrus and cuneus. The observed rightward asymmetry was attributed to changes in the topological properties of the left hemisphere in AD patients. Finally, we found that the abnormal hemispheric asymmetries of brain network properties were significantly correlated with memory performance (Rey's Auditory Verbal Learning Test). Our findings provide new insights into the lateralized nature of hemispheric disconnectivity and highlight the potential for using hemispheric asymmetry of brain network measures as biomarkers for AD.
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